The Bloom's syndrome gene product is homologous to RecQ helicases
about
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activityWerner SyndromeCloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testisThe human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1Mutations of a novel human RAD54 homologue, RAD54B, in primary cancerFunctional and physical interaction between WRN helicase and human replication protein AHuman RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Nuclear structure in normal and Bloom syndrome cellsModulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilonReplication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activityPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsCharacterization of the human and mouse WRN 3'-->5' exonucleaseRegulation and localization of the Bloom syndrome protein in response to DNA damageThe Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesThe Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth controlStructural and functional analyses of disease-causing missense mutations in Bloom syndrome proteinStructural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrityWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkStimulation of flap endonuclease-1 by the Bloom's syndrome proteinRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationHuman TOP3: a single-copy gene encoding DNA topoisomerase IIIThe Werner syndrome protein is a DNA helicaseDNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viabilityThe Bloom's syndrome gene product is a 3'-5' DNA helicaseCharacterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesThe human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cellsNucleolar localization of the Werner syndrome protein in human cellsFunctional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulatorScaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repairCharacterization of the enzymatic activity of hChlR1, a novel human DNA helicaseRecql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers.UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationIdentification of RecQL1 as a Holliday junction processing enzyme in human cell linesThe Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalphaBLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesInteraction between the N-terminus of human topoisomerase I and SV40 large T antigenRequirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae
P2860
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P1343
Q21145897-1C9B9D2E-4670-403B-AA3D-80403CA2F6EAQ21146988-A0206A16-02B1-4210-9CAC-F2571B1CE73FQ22003998-919961FA-DC0B-4DB3-9D06-733D9AA25165Q22009947-4CBE9BD5-6EFB-45FB-BF7F-B80E106431C8Q22009960-99614875-2C46-43DD-BCBC-8D271CF7568DQ22010009-6F66B8C3-CE61-480D-8CE1-440F4B03A044Q22253320-01E2D177-89DF-4184-82CB-6DDB52E69F06Q22253976-FB7D5AAC-60D1-46FF-8D70-0EA263B6682FQ22254010-35D57638-EFBE-4E79-A528-0FA54974CD6EQ22254162-AFD69C20-5CAC-4B3A-85F9-F33DACD61AE3Q22254376-FBCECBAA-0D34-4B26-ABEC-3271CD74EB09Q22254412-28AEA6F3-E6A8-42E0-9C34-2B13D17A7D6AQ24291133-670B94CF-C925-4B7E-8E38-8213D0AECE64Q24291390-D0A45DFF-4127-4DFB-B9AC-08E5A073502BQ24292118-AA15BE8F-34BA-420D-82E2-99BAF033907AQ24294274-FB07BE36-E0A8-4CEA-BC63-E331BBC793B7Q24294776-C9BA33E7-0B46-4ED1-85DA-F82DCE5B7506Q24298321-EE64B25E-57FC-4F33-AAAF-62DB9F0C8059Q24301121-8766A88B-BF96-48C3-A5B2-FB9A45D0E505Q24302463-7F0BAE33-FB19-4B62-844C-379AA6F44165Q24306868-73F474DA-0273-40E6-81B0-1FDDB11898AEQ24308917-6B50B6B3-3A59-432A-B9FD-7D6CF1919C9DQ24310486-7D4D5F09-06A2-4A0C-BBF7-3B939275D9D2Q24310507-E44B0D91-3AF4-46D9-9294-F6D5169E2567Q24310523-89CDBD56-AD19-4297-8F0D-89CA8B50D05DQ24316865-88D6A766-AA27-4607-ACD8-08D0744F1556Q24317166-AB4C4644-1385-4E16-B289-2081969E1738Q24322863-987F5A30-94F0-407E-9132-4FB6F89018C4Q24323083-DF5F4A27-C9DF-4C9F-964E-C1FFB5F362FAQ24323327-458D9285-034C-46D2-A640-1C1695B56A86Q24336403-9480D854-EAC8-4A0F-8537-ED00B63C2F9FQ24336963-BA216E1B-2F76-4FC6-8E22-4584AFE026E8Q24515331-A013378B-9B4F-47D7-A708-E2102B3D90F6Q24522689-BE26A986-6001-4BAC-A031-DAA925ACB421Q24531288-0C27A5DD-AEA6-42AE-984F-70CC4E40CEB9Q24536291-CC5E0C4E-E46B-4E56-88C7-D85704BD8D11Q24537672-CFABB2DD-4433-40AD-BBC4-A1447BFBB432Q24544999-CF0D18FE-F775-466E-A01C-9851B507E2A9Q24547088-A6EDB417-4DE7-4C06-8425-8CB6F48344EFQ24548169-6CE1C6DC-AD78-4028-8F16-93D2E2C51495
P2860
The Bloom's syndrome gene product is homologous to RecQ helicases
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The Bloom's syndrome gene product is homologous to RecQ helicases
@ast
The Bloom's syndrome gene product is homologous to RecQ helicases
@en
The Bloom's syndrome gene product is homologous to RecQ helicases
@en-gb
The Bloom's syndrome gene product is homologous to RecQ helicases
@nl
type
label
The Bloom's syndrome gene product is homologous to RecQ helicases
@ast
The Bloom's syndrome gene product is homologous to RecQ helicases
@en
The Bloom's syndrome gene product is homologous to RecQ helicases
@en-gb
The Bloom's syndrome gene product is homologous to RecQ helicases
@nl
prefLabel
The Bloom's syndrome gene product is homologous to RecQ helicases
@ast
The Bloom's syndrome gene product is homologous to RecQ helicases
@en
The Bloom's syndrome gene product is homologous to RecQ helicases
@en-gb
The Bloom's syndrome gene product is homologous to RecQ helicases
@nl
P2093
P3181
P1433
P1476
The Bloom's syndrome gene product is homologous to RecQ helicases
@en
P2093
D J Lennon
J Straughen
M Proytcheva
P304
P3181
P356
10.1016/0092-8674(95)90105-1
P407
P577
1995-11-17T00:00:00Z