P688
Oligomeric ring structure of the Bloom's syndrome helicaseAssociation of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cellsNuclear structure in normal and Bloom syndrome cellsPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsRegulation and localization of the Bloom syndrome protein in response to DNA damageThe Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesThe N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth controlBLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairStructural and functional analyses of disease-causing missense mutations in Bloom syndrome proteinTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesCharacterization and mutational analysis of the RecQ core of the bloom syndrome proteinThe Bloom's syndrome gene product is a 3'-5' DNA helicaseBLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signalThe Bloom's syndrome gene product is homologous to RecQ helicasesBloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesThe Werner and Bloom syndrome proteins catalyze regression of a model replication forkA major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpointScaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repairStructure and function of the regulatory HRDC domain from human Bloom syndrome proteinStructure of human Bloom's syndrome helicase in complex with ADP and duplex DNATelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligandsCrystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changesA helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.
P921
Q22009949-50723E23-7BEF-404B-B298-C7FA2E5B0A1FQ22253365-6BD5F0B3-B9EB-46FB-947D-87282DA7DD5FQ22253976-7FBF2A5A-9E1F-49E4-B6F6-A98E601A499EQ22254376-F8EC7F4B-9B48-4590-B6BC-8EE4E0019CBAQ24291133-7A6CEB89-850E-41CB-932E-47FBE22DCC46Q24291390-994E6E1D-19BF-403C-AB0A-9D1F34725AB9Q24291547-80506A42-CF5F-4896-B55B-E8A06B1CACB9Q24292118-2CA5F091-34B9-4AF9-848F-9498E4B8B373Q24293244-B17032A3-2EBF-4D11-8C75-927C51E81519Q24294274-8306E567-1AD5-4178-AA40-E3232EBCEB31Q24304488-77EBD9CF-D036-403B-93B5-146D1687D77FQ24305956-25D813FF-8E13-49B9-BAB0-D2596B7132C5Q24310523-BA5441AF-37EE-4D17-A686-7AF5F564EBAAQ24310784-67ABD3D7-2034-4791-8179-E3EF5D16D16AQ24313440-C0F3CADF-7A10-4671-9594-89F6F9991F99Q24317166-F9CBBF94-6243-4709-AA60-E536F822C509Q24317819-91FE14D0-0FE4-4929-8EA2-1166803CB5B9Q24323128-AE8460C9-4F7A-40E0-B314-01F9525D004CQ24336963-6843A1D2-163A-4125-9321-E3F93C5C29B7Q27663564-16A3CF18-AAB4-4239-8EED-DC7506E89D2AQ27690211-3A1B6586-AF7C-46C6-AB0C-1F85BA7FD933Q28116259-0B6E9519-2CFA-4FF9-981B-F31B18F9BD92Q28854554-442D14D3-291B-4676-83FE-B71F58598F59Q31814838-EB90D773-4DB4-4E13-A8C7-BDE7FAAD2C58Q31814841-6B5659AE-C954-4293-916C-97CB8506CA75
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in BLM RecQ like helicase
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
BLM RecQ like helicase
@en
BLM RecQ like helicase
@nl
BLM
@uk
Bloom-Syndrom-Protein
@de
布盧姆綜合症蛋白
@zh
type
label
BLM RecQ like helicase
@en
BLM RecQ like helicase
@nl
BLM
@uk
Bloom-Syndrom-Protein
@de
布盧姆綜合症蛋白
@zh
altLabel
BLM
@en
Bloom syndrome RecQ like helicase
@en
Bloom syndrome protein
@en
Bloom syndrome, RecQ helicase-like
@en
DNA helicase, RecQ-like type 2
@en
RecQ2
@de
RecQ2
@en
recQ protein-like 3
@en
prefLabel
BLM RecQ like helicase
@en
BLM RecQ like helicase
@nl
BLM
@uk
Bloom-Syndrom-Protein
@de
布盧姆綜合症蛋白
@zh
P361
P527
P637
P638
P680
P681
P682
P705
P352
P6366
P31
P352
P361
P527
P6366
2780640936
P637
NP_001274175
NP_001274176
NP_001274177
XP_006720695
XP_011520183
XP_011520184
P638
P680
P681
P682
P702
P703
P705
ENSP00000347232
ENSP00000453359
ENSP00000454158
ENSP00000497646