Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
about
Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilizationFunctional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1BH3 domains other than Bim and Bid can directly activate Bax/BakSynthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer modelsA novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathwaysSmall-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyTaspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosisThe Bcl-2 apoptotic switch in cancer development and therapyBcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapySmall-molecule Bcl-2 antagonists as targeted therapy in oncologyCombinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90mir-29 regulates Mcl-1 protein expression and apoptosisBH3 mimetics to improve cancer therapy; mechanisms and examplesTreatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer AgentsBcl-2 antagonists: a proof of concept for CLL therapyStructural insights into the transcription-independent apoptotic pathway of p53The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsTargeting Mcl-1 for the therapy of cancerApoptotic agentsGenetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerCrystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 familyA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsMcl-1-Bim complexes accommodate surprising point mutations via minor structural changesApoptotic Regulation by MCL-1 through HeterodimerizationThe MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerDiscovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based DesignMitochondrial apoptosis and BH3 mimeticsSurvival regulation of leukemia stem cellsEfficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapyThr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancerOncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cellsBM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivoMitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating DrugsSignificant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug TreatmentInhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXAPyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells.The use of therapeutic peptides to target and to kill cancer cells.A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.
P2860
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P2860
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@ast
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en-gb
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@nl
type
label
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@ast
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en-gb
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@nl
prefLabel
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@ast
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en-gb
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@nl
P2093
P50
P3181
P1433
P1476
Mechanisms of apoptosis sensit ...... -737 in acute myeloid leukemia
@en
P2093
David Harris
Dayong Zhai
Frank C Marini
Ismael Samudio
James McCubrey
John C Reed
Julie C Watt
Maria Soengas
Martin Dietrich
Monique Verhaegen
P304
P3181
P356
10.1016/J.CCR.2006.10.006
P407
P577
2006-11-01T00:00:00Z