Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 - Test2 - elhamkhani - TriplyDB

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

http://www.wikidata.org/entity/Q24647585

about

Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion Progress of molecular targeted therapies for prostate cancers Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers.Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion Mitochondria targeting nano agents in cancer therapeutics (Review)Induction of premature senescence by hsp90 inhibition in small cell lung cancer Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.A neuronal network of mitochondrial dynamics regulates metastasis.Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma.Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.Insight into nanoparticle cellular uptake and intracellular targeting Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.Signaling the mitochondrial unfolded protein response.Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.Sorafenib exerts anti-glioma activity in vitro and in vivo.Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration Disabling mitochondrial reprogramming in cancer Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells.Broad targeting of resistance to apoptosis in cancer.Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy.Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells.Hsp90 regulation of mitochondrial protein folding: from organelle integrity to cellular homeostasis

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P2860

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

http://www.wikidata.org/entity/Q24647585

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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type

label

Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

@nl

prefLabel

Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

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Journal of Clinical Investigation

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Combinatorial drug design targ ...... trolled by mitochondrial Hsp90

@en

P2093

Bradley Scroggins

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Dario C Altieri

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Ho Young Song

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Janet Plescia

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Kristin Beebe

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Len Neckers

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P2860

Hsp90: a specialized but essential protein-folding tool

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

Disassembly of transcriptional regulatory complexes by molecular chaperones

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

The consensus coding sequences of human breast and colorectal cancers

The genomic landscapes of human breast and colorectal cancers

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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454-464

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4754303

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10.1172/JCI37613

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P433

3

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119

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Giorgio Colombo

Byoung Heon Kang

Massimiliano Meli

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2009-02-23T00:00:00Z

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19229106

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2648691

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