The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins
about
PML nuclear bodiesRNF4 interacts with both SUMO and nucleosomes to promote the DNA damage responseInteractions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID FamiliesMAGE-RING protein complexes comprise a family of E3 ubiquitin ligasesCrosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA bindingPurification of proteins associated with specific genomic LociRegulation of WASH-dependent actin polymerization and protein trafficking by ubiquitinationTelomeres in aging and disease: lessons from zebrafishFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureThe cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodiesAlternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progressionSmc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisionsTimeless links replication termination to mitotic kinase activationStructural and Functional Insights into the Roles of the Mms21 Subunit of the Smc5/6 ComplexSumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1.The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeNoncanonical views of homology-directed DNA repairSUMO-mediated regulation of DNA damage repair and responsesNucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1GNL3L stabilizes the TRF1 complex and promotes mitotic transitionATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresTelomeric DNA mediates de novo PML body formationWRN loss induces switching of telomerase-independent mechanisms of telomere elongationUSP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental DisorderNEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradationSUMO and Chromatin Remodeling.Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line.Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis.Smc5/6 maintains stalled replication forks in a recombination-competent conformation.SUMO Wrestles with RecombinationRegulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modificationThe protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.SUMOylation and de-SUMOylation in response to DNA damage.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairMultiple Mechanisms Contribute To Telomere Maintenance.Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
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P2860
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@ast
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en-gb
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
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type
label
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@ast
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en-gb
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@nl
prefLabel
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@ast
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en-gb
The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@nl
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The SMC5/6 complex maintains t ...... n of telomere-binding proteins
@en
P2093
Hongtao Yu
Patrick Ryan Potts
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P304
P3181
P356
10.1038/NSMB1259
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P577
2007-07-01T00:00:00Z
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P6179
1051355165