A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
about
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteinsBcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpointsHuman homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosisThe BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAPPartial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cellsInduction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactionsA splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitroBax directly induces release of cytochrome c from isolated mitochondriaProtein kinase C isoforms: Multi-functional regulators of cell life and deathAuto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries.Evolution of regulatory sequences in 12 Drosophila species.Bcl-2 family proteins as targets for anticancer drug design.Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated BaxBehavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations.Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family membersPeptides with anticancer use or potential.DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosisDynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid FibroblastsTargeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells.Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL.PPARgamma and Apoptosis in Cancer.Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteins.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition.Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L)Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing.NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis.An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity.Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells.A novel splice variant of the cell death-promoting protein BAX.
P2860
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P248
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P2860
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A common binding site mediates ...... zation of Bcl-2 family members
@ast
A common binding site mediates ...... zation of Bcl-2 family members
@en
A common binding site mediates ...... zation of Bcl-2 family members
@en-gb
A common binding site mediates ...... zation of Bcl-2 family members
@nl
type
label
A common binding site mediates ...... zation of Bcl-2 family members
@ast
A common binding site mediates ...... zation of Bcl-2 family members
@en
A common binding site mediates ...... zation of Bcl-2 family members
@en-gb
A common binding site mediates ...... zation of Bcl-2 family members
@nl
prefLabel
A common binding site mediates ...... zation of Bcl-2 family members
@ast
A common binding site mediates ...... zation of Bcl-2 family members
@en
A common binding site mediates ...... zation of Bcl-2 family members
@en-gb
A common binding site mediates ...... zation of Bcl-2 family members
@nl
P2093
P2860
P921
P3181
P356
P1476
A common binding site mediates ...... zation of Bcl-2 family members
@en
P2093
M McConnell
T Oltersdorf
P2860
P304
P3181
P356
10.1074/JBC.272.17.11350
P407
P577
1997-04-25T00:00:00Z