Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
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Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolutionStructural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicologyDiallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1Structural diversity of eukaryotic membrane cytochrome p450sHuman Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding ModeCrystal Structure of H2O2-dependent Cytochrome P450SP with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE POSITIONConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesStructural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpineStructure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzymeNicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 EnzymesUbiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitinationThe role of ethanol metabolism in development of alcoholic steatohepatitis in the ratInhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activityStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexesOxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction stepsLettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.Evidence of bioactivation of halomethanes and its relation to oxidative stress response in Chirostoma riojai, an endangered fish from a polluted lake in Mexico.Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate.Recent Structural Insights into Cytochrome P450 Function.Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediateInhibition of human cytochrome P450 2E1 and 2A6 by aldehydes: structure and activity relationships.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations.Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexesBioelectronic delivery of electrons to cytochrome P450 enzymesSchisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in RatsRepeated administration of ethambutol in therapeutic dose causes testes alteration and spermatogenesis disruption in Wistar rats.Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers.Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1Control of electrochemical and ferryloxy formation kinetics of cyt P450s in polyion films by heme iron spin state and secondary structureSuppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a reviewStructure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes.Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1.
P2860
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P2860
Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structures of human cytochrome ...... ight and fatty acid substrates
@ast
Structures of human cytochrome ...... ight and fatty acid substrates
@en
Structures of human cytochrome ...... ight and fatty acid substrates
@en-gb
Structures of human cytochrome ...... ight and fatty acid substrates
@nl
type
label
Structures of human cytochrome ...... ight and fatty acid substrates
@ast
Structures of human cytochrome ...... ight and fatty acid substrates
@en
Structures of human cytochrome ...... ight and fatty acid substrates
@en-gb
Structures of human cytochrome ...... ight and fatty acid substrates
@nl
altLabel
Structures of Human Cytochrome ...... IGHT AND FATTY ACID SUBSTRATES
@en
prefLabel
Structures of human cytochrome ...... ight and fatty acid substrates
@ast
Structures of human cytochrome ...... ight and fatty acid substrates
@en
Structures of human cytochrome ...... ight and fatty acid substrates
@en-gb
Structures of human cytochrome ...... ight and fatty acid substrates
@nl
P2093
P2860
P921
P3181
P356
P1476
Structures of human cytochrome ...... ight and fatty acid substrates
@en
P2093
Emily E Scott
Kathleen M Meneely
Patrick R Porubsky
P2860
P304
P3181
P356
10.1074/JBC.M805999200
P407
P577
2008-11-28T00:00:00Z