about
truncation and missense AXIN mutantsAXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexUb-RibC-AXINRibC-AXINGSK3B:AXIN1AXINub-AXINAPC truncation mutants have impaired AXIN bindingTruncated AMER1 mutants destabilize the destruction complexAXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1Expression of AXIN1 geneAssembly of the destruction complex
P527
P688
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcriptionThe ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signalingLRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingSubcellular distribution of Wnt pathway proteins in normal and neoplastic colonSmad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesionWnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylationAxin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingIdentification of WNT/beta-CATENIN signaling pathway components in human cumulus cellsDownregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 betaThe adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functionsDishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-cateninUbiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
P921
Q50256114-07A27DDE-2637-4D60-88AE-F2F36AFA1CF8Q50256117-6BFD3699-02AF-4549-865E-CC9DDF2DAADCQ50269002-344ED737-68AB-4BCA-9B50-427C0E480EFCQ50269008-3E3A76D8-17DD-4A28-82D5-E13BE31558E3Q50273474-291B75A9-A12E-4F49-9D29-2F911EB25B57Q50273584-BDADEF7F-DD22-4FF0-A61A-67F64BABF211Q50273591-4A85630A-B991-4FAA-B3B7-20AD4E4B1B3DQ50288857-D5A23504-D75A-4F36-9F2F-CE86A8121EFDQ50288863-B7700AA7-9F9F-40D5-94DE-56834097E033Q50290604-F7EDA31A-E9C3-4984-8FBD-ADFAB2A5A53AQ50298705-EA768563-F715-4CEF-8E72-FE4C95F1147CQ50298707-F476C808-8153-42F4-A5A5-530A37DFCC0E
P527
Q22011145-BF8BD24B-4641-4D91-84DB-F7F554BF3248Q24295199-8D532C65-3C3E-4956-94BA-1CD890BA6ED7Q24296778-B6ADF977-B394-4EC7-9028-836BD9F2A931Q24299327-C9886B65-D832-4B30-B267-32AF25F71033Q24299973-C29E9D8F-FD78-4F52-87E7-29537C7F43C0Q24309031-2BB0CB61-D2C3-46C2-BD51-41DA2E95941AQ24310980-6E1FA565-B66F-4A3F-9FD7-CE24AF6B64E4Q24315751-3339E817-7136-4262-85DA-ED4201A71EFFQ24316697-5F628E68-EF41-4E3A-94B3-853E7543DD58Q24318862-A178AB01-DD95-43EF-BC6D-FDFC8F177AEBQ24319688-B5C6465D-513F-48D5-B602-51B7D7FD17A5Q24336996-FC54AE50-5522-4D08-8F22-60606D18D792Q24630980-0508D8B2-2675-4F9A-B02D-F6F99C16CDB0Q28742180-0FF1D5FD-8329-403F-B050-CC032FCD8AEA
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Axin 1
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Axin 1
@en
type
label
Axin 1
@en
altLabel
AXIN1
@en
axin-1
@en
axis inhibition protein 1
@en
axis inhibitor 1
@en
fused, mouse, homolog of
@en
hAxin
@en
protein phosphatase 1, regulatory subunit 49
@en
prefLabel
Axin 1
@en
P361
P527
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P637
XP_011520984
XP_011520985
XP_011520986
XP_011520988
XP_016879234
XP_016879235
XP_016879236
XP_016879237
P638
P680
P681
P682
P702
P703
P705
ENSP00000262320
ENSP00000346935
ENSP00000416835