The TEL gene products: nuclear phosphoproteins with DNA binding properties
about
TEL is a sequence-specific transcriptional repressorTel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressorModulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS DomainThe many faces of SAMIdentification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.ETV6 in hematopoiesis and leukemia predisposition.Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL.TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation.A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus.Proteins of the ETS family with transcriptional repressor activity.Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressorThe t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitinationPosttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factorsTEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity.Mutational analysis of ETV6 in prostate carcinoma.The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity.Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.Quantification of multiple gene expression in individual cells.Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylationTEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways.The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells.Tel induces a G1 arrest and suppresses Ras-induced transformation.ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish.Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.Comparative analysis of the ETV6 gene in vertebrate genomes from pufferfish to human.v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6).Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome.DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan.DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition.MAPK and GSK3/ß-TRCP-mediated degradation of the maternal Ets domain transcriptional repressor Yan/Tel controls the spatial expression of nodal in the sea urchin embryo
P2860
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P2860
The TEL gene products: nuclear phosphoproteins with DNA binding properties
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@ast
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en-gb
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@nl
type
label
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@ast
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en-gb
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@nl
prefLabel
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@ast
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en-gb
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@nl
P2093
P50
P356
P1433
P1476
The TEL gene products: nuclear phosphoproteins with DNA binding properties
@en
P2093
Ghysdael J
Le Coniat M
Mauchauffe M
P2888
P304
P356
10.1038/SJ.ONC.1200829
P407
P577
1997-01-01T00:00:00Z
P5875
P6179
1037354960