Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
about
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinMdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayRegulation of Mutant p53 Protein ExpressionMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaMDM2 interacts with MDMX through their RING finger domainsMDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblastsMdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitinationMdmX binding to ARF affects Mdm2 protein stability and p53 transactivationHdmx modulates the outcome of p53 activation in human tumor cellsMDM2 and MDMX: Alone and together in regulation of p53Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.MDM4 (MDMX) and its Transcript Variants.Identification and characterization of the first small molecule inhibitor of MDMXMdm2: the ups and downs.EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.Beta-peptides with improved affinity for hDM2 and hDMX.HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer.The MDM2 gene amplification databasePolymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neckThe p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.Abnormal MDMX degradation in tumor cells due to ARF deficiencyThe genetic regulation of the terminating phase of liver regeneration.Expression of p14ARF, MDM2, and MDM4 in human retinoblastoma.Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancerGuardian of corpulence: a hypothesis on p53 signaling in the fat cell.MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population.Inhibitors of MDM2 and MDMX: a structural perspective.Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation.MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells.Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.MdmX protects p53 from Mdm2-mediated degradation.HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
P2860
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P2860
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@ast
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en-gb
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@nl
type
label
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@ast
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en-gb
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@nl
prefLabel
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@ast
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en-gb
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@nl
P2093
P356
P1433
P1476
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
@en
P2093
A G Jochemsen
A J van der Eb
R C van Ham
W T Steegenga
W van der Houven van Oordt
P356
10.1006/GENO.1997.4775
P407
P577
1997-07-01T00:00:00Z