Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
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The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complexStructural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding proteinThe anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complexMolecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding proteinQuantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulationTransducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic PerspectiveHeterogeneity and complexity within the nuclease module of the Ccr4-Not complexPost-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7Structural basis for inhibition of the deadenylase activity of human CNOT6LInsights into the structure of the CCR4-NOT complex by electron microscopy.Biochemical and biophysical characterization of the deadenylase CrCaf1 from Chlamydomonas reinhardtiiInsights into the structure and architecture of the CCR4-NOT complexDeadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena.A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity.Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA.Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferationThe cellular roles of Ccr4-NOT in model and pathogenic fungi-implications for fungal virulenceBTG/TOB factors impact deadenylases.The structural basis for deadenylation by the CCR4-NOT complex.Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.Deadenylation: enzymes, regulation, and functional implications.BTG2 inhibits the proliferation, invasion, and apoptosis of MDA-MB-231 triple-negative breast cancer cells.BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria.BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach.Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.TP53 Regulates Transcription of Cell Cycle GenesTP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainThe Ccr4-Not Complex: Architecture and Structural Insights.Alternative splicing of CNOT7 diversifies CCR4-NOT functions.BTG2 binds CCR4-NOT complexBeyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms: New structural insights to unravel CCR4-NOT mRNA processing machinery.
P2860
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P2860
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@ast
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en-gb
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@nl
type
label
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@ast
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en-gb
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@nl
altLabel
Structural Basis for the Antiproliferative Activity of the Tob-hCaf1 Complex
@en
prefLabel
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@ast
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en-gb
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@nl
P2093
P2860
P921
P356
P1476
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex
@en
P2093
Junko Kawamura-Tsuzuku
Kiyohiro Takahasi
Kosei Takeuchi
Masataka Horiuchi
Nobuo Noda
Nobuyuki Muroya
Tadashi Yamamoto
Takahisa Nakamura
Toru Suzuki
P2860
P304
P356
10.1074/JBC.M809250200
P407
P577
2009-05-08T00:00:00Z