CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.
about
Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylaseTracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4EConservation of the deadenylase activity of proteins of the Caf1 family in humanIdentification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding proteinUNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinantDepletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growthRepression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complexComponents of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1The BTG2 protein is a general activator of mRNA deadenylationThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationStructural basis for the antiproliferative activity of the Tob-hCaf1 complexThe Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescenceAn unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodiesNot1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolinCNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell deathHuman Ccr4-Not complexes contain variable deadenylase subunitsA role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decayMechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylasesCytoplasmic foci are sites of mRNA decay in human cellsHuman TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylationA multiplicity of coactivators is required by Gcn4p at individual promoters in vivoDNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.Ccr4-Not complex: the control freak of eukaryotic cellsMechanisms of deadenylation-dependent decayProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsHeterogeneity and complexity within the nuclease module of the Ccr4-Not complexAtomic model of human Rcd-1 reveals anarmadillo-like-repeat protein with in vitro nucleic acid binding propertiesX-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complexThe 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzymeThe activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active siteCrystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificityThe Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.PUF proteins bind Pop2p to regulate messenger RNAs.Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases.Insights into the structure of the CCR4-NOT complex by electron microscopy.An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.The multifunctional Ccr4-Not complex directly promotes transcription elongationTpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay
P2860
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P2860
CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.
description
2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
CCR4, a 3'-5' poly(A) RNA and ...... of the cytoplasmic deadenylase
@nl
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@ast
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en-gb
type
label
CCR4, a 3'-5' poly(A) RNA and ...... of the cytoplasmic deadenylase
@nl
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@ast
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en-gb
prefLabel
CCR4, a 3'-5' poly(A) RNA and ...... of the cytoplasmic deadenylase
@nl
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@ast
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
CCR4, a 3'-5' poly(A) RNA and ...... f the cytoplasmic deadenylase.
@en
P2093
Clyde L Denis
Junji Chen
Yueh-Chin Chiang
P2860
P304
P3181
P356
10.1093/EMBOJ/21.6.1414
P407
P577
2002-03-01T00:00:00Z