The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
about
Immune signaling by RIG-I-like receptorsDDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signalingParamyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon inductionLGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responsesCytosolic Innate Immune Sensing and Signaling upon InfectionInterferon induction by RNA viruses and antagonism by viral pathogensMDA5 and LGP2: accomplices and antagonists of antiviral signal transductionRNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAsEbolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-IThe Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal DomainCrystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphateMarburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon AntagonismMDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNAGreen tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-IInduction of type I interferon by RNA viruses: cellular receptors and their substratesAn accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses.LGP2: positive about viral sensing.Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cellsFoot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication.Intracellular innate immune cascades and interferon defenses that control hepatitis C virusInterplay between innate immunity and negative-strand RNA viruses: towards a rational modelLGP2 expression is enhanced by interferon regulatory factor 3 in olive flounder, Paralichthys olivaceus.Ebolavirus VP35 is a multifunctional virulence factor.MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNASensing of viral nucleic acids by RIG-I: from translocation to translationRIG-I self-oligomerization is either dispensable or very transient for signal transduction.Poly(I:C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88.Low-variance RNAs identify Parkinson's disease molecular signature in bloodActivation of RIG-I-like receptor signal transduction.The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2)Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I.Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.Ancient origins of vertebrate-specific innate antiviral immunity.The laboratory of genetics and physiology 2: emerging insights into the controversial functions of this RIG-I-like receptor.
P2860
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P2860
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@ast
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en-gb
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@nl
type
label
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@ast
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en-gb
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@nl
altLabel
The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA
@en
prefLabel
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@ast
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en-gb
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@nl
P2093
P2860
P921
P3181
P356
P1476
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA
@en
P2093
C T Ranjith-Kumar
Monica T Brooks
Pingwei Li
S Dharmaiah
Xiaojun Li
P2860
P304
13881-13891
P3181
P356
10.1074/JBC.M900818200
P407
P577
2009-03-11T00:00:00Z