The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.
about
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamicsThe protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleβ-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampusPTH receptor-1 signalling-mechanistic insights and therapeutic prospectsPDE4 as a target for cognition enhancementStructures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitorsERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regionsIn vitro PKA phosphorylation-mediated human PDE4A4 activationHuman phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progressionRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertionA biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the ratSubcellular localization of cyclic nucleotide phosphodiesterase type 10A variants, and alteration of the localization by cAMP-dependent protein kinase-dependent phosphorylationNovel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylationThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cellCytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4DControl of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuitStage-specific requirement of a mitogen-activated protein kinase by Trypanosoma bruceiRetromer terminates the generation of cAMP by internalized PTH receptors.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationThe upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxinRemodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteinsUCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsEndosomal generation of cAMP in GPCR signaling.Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in MiceControl of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract.MEK Inhibitors Reverse cAMP-Mediated Anxiety in ZebrafishLocal synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.
P2860
Q24316484-E740B665-8252-4492-B260-D1013757F202Q24321738-9C910A9B-9EA4-48F1-A15E-DA15F299ED9FQ24336212-AB13B035-7BD8-4F61-BCA7-176CCCFABFA2Q24535019-7527D6AB-3D0A-4EC9-8356-549CAA02D565Q26796701-71E78CC9-3155-4C5F-8CB1-FD3D3498DF3EQ26798005-4376E720-F445-452A-B6E4-B9E817FD1331Q27008296-3989B816-D991-40A1-9BA7-3B9F43DF53DEQ27647620-54FA7C92-BCE2-40C6-B84A-B9647ACC066BQ28145238-BE17F24E-B826-4C55-9253-33B0A941048EQ28202278-3492897D-E025-451E-B6A4-BCBCB6A0A0F9Q28269917-E673812F-C774-46C8-8F11-4E18CF5508C7Q28386161-8DCED4BC-C895-4634-940B-9115A489AC62Q28388995-886E8DE7-2497-4145-89BB-94D700D8A63CQ28480922-7DBE3204-7ED7-4FBA-930D-EE0A9AD8EEE7Q28564202-AF93FD98-0E0E-439B-B38A-96A066DA8C50Q28569506-F707C07E-E905-4FDD-82C7-1CEC1FB6A4EEQ30486745-B9620727-753A-4D4E-89BE-FACD51CE18C6Q33624262-31CCD928-5322-4F66-8894-EF7D89384D95Q33799568-05833948-B497-4461-A7FB-10E0D8089D2AQ33949069-C32A85AF-9ACA-407C-9CFE-EDEA23A3D6DEQ34062870-56833EF8-84EF-46A0-973B-94FED7CEF52AQ34119706-F58FF371-D86D-495D-880F-3EB2C28B90FCQ34206033-591D731C-FF65-403D-9DE8-067F0FAD74F3Q34274140-EF260679-2A4A-423B-94A1-4F6C1A29C24DQ34819768-79BA4BB4-2EF1-4031-B7AF-CB5DD8E18FD9Q35005680-6584CB5C-C484-4231-9E9D-F04C7761A65BQ35042655-726EF270-9044-49D1-8685-2FCF9C445C85Q35044409-A7E9FFA2-AE18-4A2F-A684-CE040D3E8F38Q35044697-69135535-DBB5-4A38-83A5-AB41658E2AD3Q35047129-1AEC32E0-0DFA-457D-A361-5A7408F09D49Q35110887-72C474BE-E397-4656-989C-82999906B230Q35181565-5CB7EEF4-9321-4794-9C39-15D9392553E5Q35229437-0B87011A-4247-4758-98E9-77B94396AD01Q35535258-A9F72615-F7D8-4CAC-873D-8663E6836D71Q35563982-C12F96F7-5BCE-476F-AC70-366431AF2497Q35838089-467E937B-1953-4AA4-AEED-D8F18424B5E2Q35931515-94D9A918-A216-45BA-9AB4-BEC22E11F03EQ36156003-C84ED18D-4151-48AF-B0B0-708BAAC12848Q36215799-E5397782-3DC5-4999-890E-E8F377D21D34Q36397735-2C75E311-507B-4749-AD35-E88D48B16E69
P2860
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
The MAP kinase ERK2 inhibits t ...... y phosphorylating it at Ser579
@nl
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@ast
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@en
type
label
The MAP kinase ERK2 inhibits t ...... y phosphorylating it at Ser579
@nl
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@ast
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@en
prefLabel
The MAP kinase ERK2 inhibits t ...... y phosphorylating it at Ser579
@nl
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@ast
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@en
P2093
P2860
P356
P1433
P1476
The MAP kinase ERK2 inhibits t ...... phosphorylating it at Ser579.
@en
P2093
G S Baillie
M D Houslay
R Hoffmann
S J MacKenzie
S J Yarwood
P2860
P304
P356
10.1093/EMBOJ/18.4.893
P407
P577
1999-02-01T00:00:00Z