Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
about
Rothmund-Thomson syndromeUnwinding and rewinding: double faces of helicase?Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyRoles of Werner syndrome protein in protection of genome integrityClose encounters for the first time: Helicase interactions with DNA damageRECQL4 in genomic instability and agingThe N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motifAn essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceRecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cellsdRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.Replication protein A stimulates the Werner syndrome protein branch migration activity.The involvement of human RECQL4 in DNA double-strand break repair.Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential.Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationSenescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complexThe intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patientsRECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.Human RecQL4 helicase plays critical roles in prostate carcinogenesis.MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replicationThe Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.Borrowing nuclear DNA helicases to protect mitochondrial DNA.Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicaseRECQL4 localizes to mitochondria and preserves mitochondrial DNA integrityHuman RecQ helicases in DNA repair, recombination, and replication.The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair.RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activityEmerging players in the initiation of eukaryotic DNA replication.Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesionsDirect and indirect roles of RECQL4 in modulating base excision repair capacity.Direct inhibition of RNA polymerase II transcription by RECQL5.
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Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
description
2009 nî lūn-bûn
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2009 թուականի Մարտին հրատարակուած գիտական յօդուած
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2009 թվականի մարտին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年論文
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2009年论文
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name
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@ast
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en-gb
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@nl
type
label
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@ast
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en-gb
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@nl
prefLabel
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@ast
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en-gb
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@nl
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Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4
@en
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P2860
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10.1038/EMBOJ.2009.13
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2009-03-04T00:00:00Z