Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation - Test2 - elhamkhani - TriplyDB

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

http://www.wikidata.org/entity/Q33705012

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Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology Genome-wide comprehensive analysis of human helicases The role of RecQ helicases in non-homologous end-joining RECQL4 in genomic instability and aging Roles of DNA helicases in the maintenance of genome integrity The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes Mechanistic and biological aspects of helicase action on damaged DNA.Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.Human RECQL1 participates in telomere maintenance Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.Interaction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication.Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer.Human RecQL4 helicase plays critical roles in prostate carcinogenesis.RecQL4 helicase amplification is involved in human breast tumorigenesis.Werner syndrome with refractory cystoid macular edema and immunohistochemical analysis of WRN proteins in human retinas DNA2 drives processing and restart of reversed replication forks in human cells.The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Borrowing nuclear DNA helicases to protect mitochondrial DNA.Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins."...Rewritten in the skin": clues to skin biology and aging from inherited disease.RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity DNA helicases associated with genetic instability, cancer, and aging.Human RecQ helicases in DNA repair, recombination, and replication.The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair.A new sub-pathway of long-patch base excision repair involving 5' gap formation.RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity Emerging players in the initiation of eukaryotic DNA replication.

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P2860

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

http://www.wikidata.org/entity/Q33705012

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@ast

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@en

type

label

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@ast

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@en

prefLabel

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@ast

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@en

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Molecular and Cellular Biology

P1476

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation

@en

P2093

Alessandro Vindigni

http://www.w3.org/2001/XMLSchema#string

Arturo Falaschi

http://www.w3.org/2001/XMLSchema#string

Erika Tissino

http://www.w3.org/2001/XMLSchema#string

Jinhu Yin

http://www.w3.org/2001/XMLSchema#string

Ramiro Mendoza-Maldonado

http://www.w3.org/2001/XMLSchema#string

Raymond J Monnat

http://www.w3.org/2001/XMLSchema#string

Saravanabhavan Thangavel

http://www.w3.org/2001/XMLSchema#string

Weidong Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation and localization of the Bloom syndrome protein in response to DNA damage

Human Mcm proteins at a replication origin during the G1 to S phase transition

The Bloom's syndrome gene product is homologous to RecQ helicases

Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

Nucleolar localization of the Werner syndrome protein in human cells

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

Localization of proteins bound to a replication origin of human DNA along the cell cycle

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1382-1396

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scholarly article

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10.1128/MCB.01290-09

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6

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30

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2010-01-11T00:00:00Z

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20065033

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2832491

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