CDK targets Sae2 to control DNA-end resection and homologous recombination
about
Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeresCdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repairAn overview of Cdk1-controlled targets and processesInhibition of homologous recombination by the PCNA-interacting protein PARICtIP is required to initiate replication-dependent interstrand crosslink repairDNA polymerase POLN participates in cross-link repair and homologous recombinationCyclin-dependent kinase inhibitor therapy for hematologic malignanciesDNA resection in eukaryotes: deciding how to fix the breakDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2DNA end resection: many nucleases make light workMaintaining Genome Stability in Defiance of Mitotic DNA DamageThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiRole of Deubiquitinating Enzymes in DNA RepairTargeting the Checkpoint to Kill Cancer CellsTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeDNA double-strand break repair pathway choice and cancerSources of DNA double-strand breaks and models of recombinational DNA repairMultiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNACtIP Mutations Cause Seckel and Jawad SyndromesEnd-resection at DNA double-strand breaks in the three domains of lifeCompeting roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.Regulation of Rad51 function by phosphorylationSystematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifsCyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks.Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases.Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancerMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Factors determining DNA double-strand break repair pathway choice in G2 phaseHuman CtIP mediates cell cycle control of DNA end resection and double strand break repairEXD2 promotes homologous recombination by facilitating DNA end resectionGenetic instability in budding and fission yeast-sources and mechanismsMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairChemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells
P2860
3706c58fedd9dac6501b67f9611723373d133fec3d5ac97de6a1c8138776f8ca06ade2da507730d4431d15af9b83c1423b4d95319dcb4281274b2e5c7a1e6658c90b19ffb28311645e59e985196eafba97e498c84a1bbd3c1afdb75be64e2b6bcd5bcc70998faed30a5965e06d5b9b412be65ac8644578ded0acd6127d98464bc781cc34243689e327297e38f62dde8e77751e103180d23447000a4737cc78f9
P248
Q21144979-2FF5EDBE-C734-42D2-BE5C-03593E695541Q21144986-0C74D453-91F1-43D8-ACCF-A5A62C06E407Q21203553-CA17A259-183E-44A7-968C-B607272613A1Q24299258-1FAF3FF3-FA07-48BA-AEA3-BE202765D6CFQ24303573-5911FC01-0CA8-4626-A934-66FCCF9867D2Q24336826-B6A6F081-97A4-4E1B-AB8E-5D8B306903DAQ24561485-AEE88010-8E0A-43CE-888C-968DD51A2E17Q24603592-D256F5A9-0C85-42D6-97C8-FB42D38F7A0DQ24608343-C0953765-D2FD-4EA8-97DE-9982907A7FB9Q24647310-81E4F3FB-01EC-428C-989A-F57FB100ABEBQ24654725-8828B437-697B-4D8D-8EDA-F4ED73C9739DQ26738970-E12326E7-7882-4A7E-BF44-4EA1DDD2C6DCQ26747443-D91B7B94-3E5E-408A-AF63-D37578136CE7Q26773800-DFFE3D3E-F01C-4C12-BF98-2141B571900DQ26795781-43CE020A-605C-4A51-9C4B-A3D0DEC7F979Q26827580-7A62350D-D228-485B-9A35-57915F7EF41AQ26864428-097FBB77-E7C2-40DF-9F6E-21E07CC1CBBBQ26996175-9EEFEED3-32FF-4AA2-A822-2BF7E24AABF5Q27005814-6DE3A980-15E8-4E2A-ACE1-4914CC4C411FQ27012760-81628C4E-BA4E-427F-8756-61E76E8BD08CQ27335946-FE5B6689-ED54-490A-96B1-E2B92AE4F07BQ27694756-3A8F6994-B706-4004-A9FD-14DF34C4B09DQ27930908-4D8C4AC4-C5EB-4979-89AD-E93AEFF4469EQ27934340-EF3C4802-63F2-4F2B-9191-5EE30950601EQ27934845-F64CDDF2-56D7-4E74-8278-BA45CAAECC52Q27936403-AC5B91B5-E6F4-446B-8646-C1A7AC341656Q27936967-4222932F-C7F3-40A1-B07D-C8BE9643B5C2Q27937625-A6EBD1ED-6381-46EA-9F8F-BFD0E39C48D0Q27937887-93F52965-DE9C-4122-9D2F-76802A86D77DQ27939123-CD488F2D-56FA-4BE3-9443-42728672DDE0Q28000088-FCDE4924-35C0-493A-B28C-0FA4C9E8410AQ28066464-7BF61404-9F3A-4F24-9C2C-736B3A8C57A5Q28083182-FBCB6CA1-6D85-41A5-9FA6-CEAD82A603BDQ28118755-AC51B129-5406-4D9E-80AE-9F230FC812A1Q28118984-CB19FF50-4D46-433B-BF41-03AFD6FDB4EEQ28119210-0E610AA3-7FA4-4291-B961-FD2AE3F9FE95Q28264035-33EF1651-7B09-4631-BDE9-BD93E3FD5B77Q28274000-CC0E79E2-9C86-42E2-A9A7-3155E116FFF8Q28472620-748B02EC-B6E5-4B55-AF68-6AB93E689A92Q28482509-005341CC-979C-4D39-A3FB-F656FB9E1AE9
P2860
CDK targets Sae2 to control DNA-end resection and homologous recombination
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
CDK targets Sae2 to control DNA-end resection and homologous recombination
@ast
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en-gb
CDK targets Sae2 to control DNA-end resection and homologous recombination
@nl
type
label
CDK targets Sae2 to control DNA-end resection and homologous recombination
@ast
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en-gb
CDK targets Sae2 to control DNA-end resection and homologous recombination
@nl
prefLabel
CDK targets Sae2 to control DNA-end resection and homologous recombination
@ast
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en-gb
CDK targets Sae2 to control DNA-end resection and homologous recombination
@nl
P2860
P50
P3181
P356
P1433
P1476
CDK targets Sae2 to control DNA-end resection and homologous recombination
@en
P2093
Felipe Cortés-Ledesma
P2860
P2888
P304
P3181
P356
10.1038/NATURE07215
P407
P577
2008-08-20T00:00:00Z
P5875
P6179
1031468320