Human CtIP promotes DNA end resection - Test2 - elhamkhani - TriplyDB

Human CtIP promotes DNA end resection

Human CtIP promotes DNA end resection

http://www.wikidata.org/entity/Q24646062

about

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair Human single-stranded DNA binding proteins are essential for maintaining genomic stability Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair Human SIRT6 promotes DNA end resection through CtIP deacetylation CtIP is required to initiate replication-dependent interstrand crosslink repair DNA end resection by CtIP and exonuclease 1 prevents genomic instability The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage PALB2 regulates recombinational repair through chromatin association and oligomerization CDK targets Sae2 to control DNA-end resection and homologous recombination SOSS complexes participate in the maintenance of genomic stability A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia DNA resection in eukaryotes: deciding how to fix the break Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 Targeting DNA topoisomerase II in cancer chemotherapy DNA end resection: many nucleases make light work DNA End Resection: Facts and Mechanisms Role of Deubiquitinating Enzymes in DNA Repair Molecular mechanisms of etoposide The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair Chromatin perturbations during the DNA damage response in higher eukaryotes Targeting the Checkpoint to Kill Cancer Cells Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis Nucleases in homologous recombination as targets for cancer therapy Modulation of DNA damage and repair pathways by human tumour viruses

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Human CtIP promotes DNA end resection

http://www.wikidata.org/entity/Q24646062

description

2007 nî lūn-bûn

@nan

2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Human CtIP promotes DNA end resection

@ast

Human CtIP promotes DNA end resection

@en

Human CtIP promotes DNA end resection

@nl

type

label

Human CtIP promotes DNA end resection

@ast

Human CtIP promotes DNA end resection

@en

Human CtIP promotes DNA end resection

@nl

prefLabel

Human CtIP promotes DNA end resection

@ast

Human CtIP promotes DNA end resection

@en

Human CtIP promotes DNA end resection

@nl

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Human CtIP promotes DNA end resection

@en

P2093

Julia Coates

http://www.w3.org/2001/XMLSchema#string

Martin Mistrik

http://www.w3.org/2001/XMLSchema#string

Richard Baer

http://www.w3.org/2001/XMLSchema#string

Shuang Fu

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of a carboxy-terminal BRCA1 interacting protein

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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P304

509-14

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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1240916

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P356

10.1038/NATURE06337

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P407

P433

7169

http://www.w3.org/2001/XMLSchema#string

P478

450

http://www.w3.org/2001/XMLSchema#string

P50

Stephen P Jackson

Alessandro A Sartori

P577

2007-11-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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5879832

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1051713472

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17965729

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2409435

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