Deep mutational scanning: a new style of protein science
about
Causes of evolutionary rate variation among protein sitesHigh-Throughput Screening in Protein Engineering: Recent Advances and Future PerspectivesRational Protein Engineering Guided by Deep Mutational ScanningSort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relationsSystematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionThe Generation and Exploitation of Protein Mutability Landscapes for Enzyme EngineeringAnalysis of genetic variation and potential applications in genome-scale metabolic modelingApplications of comparative evolution to human disease geneticsDetermination of binding affinity upon mutation for type I dockerin-cohesin complexes from Clostridium thermocellum and Clostridium cellulolyticum using deep sequencingViral factors in influenza pandemic risk assessment.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated serverA Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering MutationsPotts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness.In silico Mapping of Protein Unfolding Mutations for Inherited DiseasePersonalised proteome analysis by means of protein microarrays made from individual patient samples.Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing.Software for the analysis and visualization of deep mutational scanning data.The role of functional data in interpreting the effects of genetic variationThe background puzzle: how identical mutations in the same gene lead to different disease symptoms.Identifying pathogenicity of human variants via paralog-based yeast complementation.Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encodedA platform for functional assessment of large variant libraries in mammalian cells.ScaffoldSeq: Software for characterization of directed evolution populations.Massively parallel single-amino-acid mutagenesisMeasuring the activity of protein variants on a large scale using deep mutational scanning.Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.High-resolution sequence-function mapping of full-length proteins.Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and FunctionalityDissecting enzyme function with microfluidic-based deep mutational scanningSystematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsDe novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries.Evolving new protein-protein interaction specificity through promiscuous intermediates.Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.Novel Rhizosphere Soil Alleles for the Enzyme 1-Aminocyclopropane-1-Carboxylate Deaminase Queried for Function with an In Vivo Competition AssayCoupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment.Hierarchy and extremes in selections from pools of randomized proteinsHigh-throughput evaluation of synthetic metabolic pathways.Predicted Molecular Effects of Sequence Variants Link to System Level of DiseaseDeep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations.Plasmid-based one-pot saturation mutagenesis.
P2860
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P2860
Deep mutational scanning: a new style of protein science
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Deep mutational scanning: a new style of protein science
@ast
Deep mutational scanning: a new style of protein science
@en
type
label
Deep mutational scanning: a new style of protein science
@ast
Deep mutational scanning: a new style of protein science
@en
prefLabel
Deep mutational scanning: a new style of protein science
@ast
Deep mutational scanning: a new style of protein science
@en
P2860
P356
P1433
P1476
Deep mutational scanning: a new style of protein science
@en
P2093
Douglas M Fowler
Stanley Fields
P2860
P2888
P304
P356
10.1038/NMETH.3027
P577
2014-08-01T00:00:00Z