Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition
about
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelADisrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancerManipulation of the host protein acetylation network by human immunodeficiency virus type 1Bromodomain proteins in HIV infectionThe bromodomain: from epigenome reader to druggable targetProtein lysine acetylation by p300/CBPOptimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsStructure-Guided Design of Potent Diazobenzene Inhibitors for the BET BromodomainsStructural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBPSelective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage ProgressionDifferent orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomainTargeting bromodomains: epigenetic readers of lysine acetylationTargeting BET bromodomains for cancer treatmentSegmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase AControl of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genesBrd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expressionPrivileged diazepine compounds and their emergence as bromodomain inhibitors.Role of transcription factor acetylation in diabetic kidney disease.Writers and readers of histone acetylation: structure, mechanism, and inhibitionDifferences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice.BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction.Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.BET bromodomain inhibitors: a patent review.BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapyHuman immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets.Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.Treating type-1 diabetes with an epigenetic drugBRD4 inhibitor inhibits colorectal cancer growth and metastasis.Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cellsBrd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cellsSynergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinibDesign and characterization of bivalent BET inhibitors.Scaling the druggability landscape of human bromodomains, a new class of drug targets.Multiple functional linear model for association analysis of RNA-seq with imaging.Beyond receptors and signaling: epigenetic factors in the regulation of innate immunityHigh level of BRD4 promotes non-small cell lung cancer progression.Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.
P2860
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P2860
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@ast
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en-gb
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@nl
type
label
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@ast
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en-gb
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@nl
altLabel
Down-regulation of NF- B Trans ...... ney Disease by BRD4 Inhibition
@en
Down-regulation of NF- B Trans ...... ney Disease by BRD4 Inhibition
@en
prefLabel
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@ast
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en-gb
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@nl
P2093
P2860
P921
P3181
P356
P1476
Down-regulation of NF-κB trans ...... ney disease by BRD4 inhibition
@en
P2093
Alexander N Plotnikov
Elena Rusinova
Guangtao Zhang
Guillermo Gerona-Nevarro
Jennifer Joshua
John Cijiang He
Michael Ohlmeyer
Ming-Ming Zhou
Natasha Moshkina
P2860
P304
P3181
P356
10.1074/JBC.M112.359505
P407
P577
2012-08-17T00:00:00Z