Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
about
Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsUse of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilizationProteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavageMonosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradationNoxa is necessary for hydrogen peroxide-induced caspase-dependent cell deathNoxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsMembrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationHeterodimerization of BAK and MCL-1 activated by detergent micellesBH3 domains other than Bim and Bid can directly activate Bax/BakThe vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein BaxBcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpointsMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisThe Bcl-2 apoptotic switch in cancer development and therapySmall-molecule Bcl-2 antagonists as targeted therapy in oncologyBH3 mimetics to improve cancer therapy; mechanisms and examplesPuma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionInhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondriaMitochondria, cholesterol and cancer cell metabolismPotential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisionsBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsApoptotic agentsSignaling cross-talk in the resistance to HER family receptor targeted therapyMito-priming as a method to engineer Bcl-2 addiction.BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAKA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationCompleting the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with BimBAX activation is initiated at a novel interaction siteConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsMcl-1-Bim complexes accommodate surprising point mutations via minor structural changesDeterminants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLApoptotic Regulation by MCL-1 through HeterodimerizationEvidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAXIntrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic ActivityEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainBID-induced structural changes in BAK promote apoptosisStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsMitochondrial apoptosis and BH3 mimeticsPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
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P2860
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@ast
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en-gb
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@nl
type
label
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@ast
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en-gb
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@nl
prefLabel
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@ast
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en-gb
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@nl
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P921
P3181
P1433
P1476
Mitochondria primed by death s ...... apoptotic BCL-2 family members
@en
P2093
Anthony Letai
Mari Nishino
Michael Certo
Scott A Armstrong
Stanley Korsmeyer
P304
P3181
P356
10.1016/J.CCR.2006.03.027
P407
P577
2006-05-01T00:00:00Z