Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
about
Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreDiscovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomesStructural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsBh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisEpistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL.BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranesPredictive Bcl-2 family binding models rooted in experiment or structure.Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspectiveOncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane.Redefining the BH3 Death Domain as a 'Short Linear Motif'.Structural biology of the intrinsic cell death pathway: what do we know and what is missing?After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesCell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.Oncogenic protein interfaces: small molecules, big challenges.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization.On the intrinsic disorder status of the major players in programmed cell death pathways.Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine.Molecular dynamics study of segment peptides of Bax, Bim, and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein.BCL-2 family proteins: changing partners in the dance towards death.Enhanced Sampling of Intrinsic Structural Heterogeneity of the BH3-Only Protein Binding Interface of Bcl-xL.The long unstructured region of Bcl-xl modulates its structural dynamics.Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.Deciphering the crucial residues involved in heterodimerization of Bak peptide and anti-apoptotic proteins for apoptosis.Mannich bases of 1,2,4-triazole-3-thione containing adamantane moiety: Synthesis, preliminary anticancer evaluation, and molecular modeling studies.Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.Allostery in BAX protein activation.
P2860
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P248
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P2860
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@ast
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en-gb
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@nl
type
label
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@ast
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en-gb
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@nl
altLabel
Mutation to Bax beyond the BH3 ...... roteins and Promotes Apoptosis
@en
prefLabel
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@ast
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en-gb
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@nl
P2093
P2860
P921
P3181
P356
P1476
Mutation to Bax beyond the BH3 ...... roteins and promotes apoptosis
@en
P2093
Ahmad Z Wardak
Geoff V Thompson
Peter E Czabotar
Peter M Colman
W Douglas Fairlie
P2860
P304
P3181
P356
10.1074/JBC.M110.161281
P407
P50
P577
2011-03-04T00:00:00Z