Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
about
Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyMicrocephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayTumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activationTOPORS, implicated in retinal degeneration, is a cilia-centrosomal proteinNek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylationThe forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesRestoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiationInhibition of the mitotic exit network in response to damaged telomeres.PLK1, A Potential Target for Cancer TherapyChk2 regulates cell cycle progression during mouse oocyte maturation and early embryo developmentCell death by mitotic catastrophe: a molecular definitionPhospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage responseCHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.Double-strand DNA breaks recruit the centromeric histone CENP-A.Differential regulation of centrosome integrity by DNA damage response proteins.Mitotic catastrophe and cell death induced by depletion of centrosomal proteins.Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk2 prevents mitotic exit when the majority of kinetochores are unattached.ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission.Mitotic crisis: the unmasking of a novel role for RPAMutations in LRRC50 predispose zebrafish and humans to seminomas.Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationStabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation.Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibitionBuilding a human kinase gene repository: bioinformatics, molecular cloning, and functional validationActivation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) miceCHK2 kinase in the DNA damage response and beyondGive me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling eventsEXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Regulation of cell cycle checkpoints by polo-like kinases.Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma.Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection.High expression of N-acetyltransferase 10: a novel independent prognostic marker of worse outcome in patients with hepatocellular carcinoma.Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
P2860
Q21245716-F4AB5045-F830-4094-B5EF-A7E9F5C09B5BQ22337187-E8CFC989-9EEE-4554-9BA8-9726DE972C49Q24302278-094E4EE2-FD0D-4776-88C5-3C8561B1AAFBQ24311887-362FEEC5-89E6-41FE-A27D-C4A69465362DQ24316522-7F2F3484-F75F-4189-8E23-947A88A844CDQ24336691-FEC9513C-DAEE-4B33-8281-8191EA73323BQ24556578-7E2BC064-3E9D-469E-9774-F5C78B2C5166Q24563808-E09AA642-D9BB-473C-944F-D96E5C63ADC0Q27930771-24460A3F-6BF1-42E8-8648-C9E58C6F751BQ28078772-E04AFDDB-EB22-4C75-BA6B-2822E2FB7964Q28235315-0F907B1D-BF65-40D6-830C-5B3003E95BE8Q28255830-91035C58-2CAD-4557-8B8F-514B05502243Q28297156-9F60E95C-2515-4CD9-8D87-F0143B4AC0A0Q28387717-7BE0918E-3C41-489A-B14C-B694199FE7A6Q30436771-776C8DCE-0F96-48BD-BFBF-EFBD13B48D22Q30483874-7E21B19A-8177-4CC9-ACBB-AF7F2921F1D6Q30539373-784E5B8B-64D4-4467-B849-43C8FA6F40ACQ30540177-2DFE9421-4AB4-4EEC-A8BD-3126B9E488B4Q30577899-FF19C796-7413-4309-BF4D-048D13FA96C5Q30654027-BE8BBA35-1DA7-4706-BB37-29F1473A833EQ30857441-7896D967-E45D-438F-AC59-A415CA4E7306Q31115616-AECDDDBA-9D9A-4093-8CEC-8D0D50B9B846Q33292501-5A6E540D-18FF-4A90-8F5F-8EEB0DA2876AQ33528933-63D9AD69-5F71-44BA-BFED-3F4BC3006163Q33717163-DFFEE384-1145-4737-8556-DC7B5E977794Q33832728-5E8AC418-E831-4833-9E09-BB13A693B09EQ33852226-FB8F22D4-B172-4ED3-97F9-43B27AE5E052Q34347570-20D83F43-CFA2-4D66-9CCD-372984B5C467Q34379535-0465329D-8A74-4AB2-813E-2DA6BCB143C7Q34583793-87698D37-A67A-427A-A098-C0A365292689Q34620852-15DC506E-380A-4BE8-8DAB-4F35992B302CQ34977480-643C955A-3A64-4856-99CC-6D91A3F0A674Q35051157-D7F8AC21-7B68-454D-B4B2-F6A8C9F74A47Q36002464-CEEBA897-986E-4870-9C23-330A93F86A99Q36004643-B5621E12-B1EE-43C8-A319-98DE82205CC4Q36054290-33240A4A-EA05-4C1B-B507-EC5A48EE7588Q36080515-491B5019-90FA-48BA-A960-C64F2A919A4AQ36287378-ED765A3D-35F9-4B03-9C5C-A29668CCCA68Q36464614-BBC5BF61-552A-4DE1-BBBD-4BBDE3280400Q36496174-4D2806C7-CAAF-42E3-B8E8-D16656E386F7
P2860
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@ast
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en-gb
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@nl
type
label
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@ast
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en-gb
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@nl
prefLabel
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@ast
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en-gb
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@nl
P2093
P2860
P356
P1476
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
@en
P2093
David F Stern
Lyuben Tsvetkov
Xingzhi Xu
P2860
P304
P356
10.1074/JBC.M211202200
P407
P577
2003-03-07T00:00:00Z