Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro - Test2 - elhamkhani - TriplyDB

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

http://www.wikidata.org/entity/Q24656275

about

Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication Chk2 activation dependence on Nbs1 after DNA damage Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange MDC1 is a mediator of the mammalian DNA damage checkpoint TAO kinases mediate activation of p38 in response to DNA damage The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379 The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication The mismatch repair system is required for S-phase checkpoint activation Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody Involvement of human MOF in ATM function ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2 Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Ultrasensitivity in the Regulation of Cdc25C by Cdk1 Irofulven induces replication-dependent CHK2 activation related to p53 status Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study Mutation analysis of the CHK2 gene in breast carcinoma and other cancers The associations between Parkinson's disease and cancer: the plot thickens Hydrogen peroxide - production, fate and role in redox signaling of tumor cells DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2 Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer Replication fork instability and the consequences of fork collisions from rereplication Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways

P2860

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P2860

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

http://www.wikidata.org/entity/Q24656275

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@ast

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@en

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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type

label

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@ast

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@en

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@nl

prefLabel

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@ast

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@en

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

@en

P2093

A Ogawa

http://www.w3.org/2001/XMLSchema#string

G Rotman

http://www.w3.org/2001/XMLSchema#string

K Tamai

http://www.w3.org/2001/XMLSchema#string

S J Elledge

http://www.w3.org/2001/XMLSchema#string

Y Shiloh

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Binding and modulation of p53 by p300/CBP coactivators

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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10389-94

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scholarly article

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3938067

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10.1073/PNAS.190030497

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19

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P478

97

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P50

Shuhei Matsuoka

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2000-09-12T00:00:00Z

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12347703

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10973490

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P921

phosphorylation

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27034

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