Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
about
Polycomb group targeting through different binding partners of RING1B C-terminal domainThe putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progressionThe Polycomb-associated protein Rybp is a ubiquitin binding proteinRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexUbiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorBMI1-mediated histone ubiquitylation promotes DNA double-strand break repairMolecular genetic analysis of Suppressor 2 of zeste identifies key functional domainsRole of hPHF1 in H3K27 methylation and Hox gene silencingBMI1: A Biomarker of Hematologic MalignanciesA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationStructure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transBIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimerStructure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF HomologsBMI1-RING1B is an autoinhibited RING E3 ubiquitin ligaseDirect Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeastPRC1 is taking the lead in PcG repressionThe E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug targetSwitches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination systemA C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTRRAWUL: a new ubiquitin-like domain in PRC1 ring finger proteins that unveils putative plant and worm PRC1 orthologsHistone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzle.Molecular architecture of polycomb repressive complexesHigh BMI1 mRNA expression in peripheral whole blood is associated with favorable prognosis in advanced non-small cell lung cancer patientsTargeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation.Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domainBmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neuronsRNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways.Polycomb group complexes--many combinations, many functions.Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation.(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cellsSulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells.dRYBP counteracts chromatin-dependent activation and repression of transcriptionBmi-1: At the crossroads of physiological and pathological biology.A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein levelHistone demethylases and cancer.
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P2860
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@ast
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en-gb
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@nl
type
label
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@ast
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en-gb
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@nl
prefLabel
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@ast
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en-gb
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@nl
P2093
P2860
P921
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P1476
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
@en
P2093
Michael P Myers
Rui-Ming Xu
Zhizhong Li
P2860
P304
P3181
P356
10.1074/JBC.M602461200
P407
P577
2006-07-21T00:00:00Z