Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
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Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathologyOptineurin negatively regulates the induction of IFNbeta in response to RNA virus infectionUbiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteinsNEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domainEnhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucomaAtypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review seriesTNF biology, pathogenic mechanisms and emerging therapeutic strategiesFunctional analysis of optineurin and some of its disease-associated mutantsGlaucomatous neurodegeneration: an eye on tumor necrosis factor-alphaLinear ubiquitination signals in adaptive immune responsesPosttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma geneLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationCrystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitinOptineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinProcessing of optineurin in neuronal cellsEffects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cellsM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsThe TBK1-binding domain of optineurin promotes type I interferon responsesMutations of optineurin in amyotrophic lateral sclerosisRegulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein.Impairment of protein trafficking upon overexpression and mutation of optineurin.The IKK complex, a central regulator of NF-kappaB activationRIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurinE50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Does Huntingtin play a role in selective macroautophagy?The IκB kinase complex in NF-κB regulation and beyond.TNF-alpha signaling in glaucomatous neurodegenerationTBK1 gene duplication and normal-tension glaucoma.NF-κB and cancer: a paradigm of Yin-Yang.Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina.Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
P2860
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P2860
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@ast
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en-gb
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@nl
type
label
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@ast
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en-gb
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@nl
prefLabel
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@ast
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en-gb
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@nl
P2093
P921
P3181
P1433
P1476
Optineurin negatively regulate ...... ith NEMO for ubiquitinated RIP
@en
P2093
Chuan-Jin Wu
Guozhi Zhu
Jonathan D Ashwell
Yongge Zhao
P304
P3181
P356
10.1016/J.CUB.2007.07.041
P407
P577
2007-08-21T00:00:00Z