Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
about
Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaFunctional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferasesAcyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine PhosphoribosyltransferaseSynthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine PhosphoribosyltransferasesHelicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesisSignal Peptidase Complex Subunit 1 and Hydroxyacyl-CoA Dehydrogenase Beta Subunit Are Suitable Reference Genes in Human LungsPurine and pyrimidine pathways as targets in Plasmodium falciparum.Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitorCrystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.Plasmodium falciparum: new molecular targets with potential for antimalarial drug development.The acyclic nucleoside phosphonates (ANPs): Antonín Holý's legacy.Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.From crystal to compound: structure-based antimalarial drug discovery.Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.Synthesis and biological evaluation of novel 1,2,3-triazolonucleotides.Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker.Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.Synthesis of α-branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases.Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity.Structural and dynamical correlations in PfHGXPRT oligomers: A molecular dynamics simulation study.Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase.Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring.
P2860
Q27014881-12C2902E-9B53-453A-9B29-F63AD9A65D82Q27679203-B372397A-A810-4365-9000-A1D203922DD4Q27681323-BC5E42B6-50A4-42C3-A737-50F768243F94Q27702146-C279738D-0F55-454E-8B7C-D6C6AA453E5BQ30425739-F45A9E7D-BB3D-44D5-98DC-93FB249DBD0AQ35529736-5529E5D4-EDB1-473A-A622-57CC9438DFC5Q35870244-8CCA3932-60D7-4F7F-8A18-083ECBCDA4FCQ36269018-74308F15-26C3-4D9E-9092-AB83C961A33AQ37369043-34066582-21AB-4073-BC78-E0D806687147Q37626063-A99167AB-187F-4E34-8620-CC552A1AA3E1Q38097391-0256EE53-5C55-44B4-A70A-16010D8150CAQ38124799-474C6A3F-D4AC-4801-A429-D36AAAB48CF0Q38227796-F5BE3FC0-6059-45FF-A96B-37E02028CC78Q38806723-D679656C-B535-4ABB-BCA8-A16957BDDAEBQ38857408-4F260250-1158-4010-88AF-921533F6362CQ39191262-C66239C3-87DF-4B18-ADA6-FEC70CE0C458Q40154517-FC249DFF-098B-4F0A-A994-D981D4CD6076Q41186604-AD9D49B8-8F8D-4008-92F0-A286448B7594Q42549457-BCF25736-7A49-4EF3-B0CB-8C9A858B154CQ46242316-168C9270-B1E5-4630-839F-237AEC95647AQ46790764-70AEB537-2E64-4BFF-99FF-8CE55074D1DEQ50798240-9E02D081-7C2F-4995-9056-D8245BEA02C8Q51602379-0D589868-5FA0-46CC-9135-71C287EF956BQ52372835-8B9FE967-3FF9-4D5F-B9BF-DBA6C188DA37Q54284877-FDE30475-CF46-49D4-9FBA-6B11BF36AC54Q54358944-6280B3CC-3F25-4B09-8850-50538E44B9DC
P2860
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@ast
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en-gb
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@nl
type
label
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@ast
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en-gb
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@nl
prefLabel
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@ast
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en-gb
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@nl
P2093
P921
P3181
P356
P1476
Inhibition of hypoxanthine-gua ...... s of antimalarial therapeutics
@en
P2093
Dana Hocková
Dianne T Keough
John de Jersey
Lieve M J Naesens
Tina S Skinner-Adams
P304
P3181
P356
10.1021/JM900267N
P407
P577
2009-07-23T00:00:00Z