Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. - Test2 - elhamkhani - TriplyDB

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.

http://www.wikidata.org/entity/Q37369043

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Synthesis of α-branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases.Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.

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Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.

http://www.wikidata.org/entity/Q37369043

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 October 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Crystal structures and inhibit ...... ine phosphoribosyltransferase.

@en

Crystal structures and inhibit ...... ine phosphoribosyltransferase.

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type

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Crystal structures and inhibit ...... ine phosphoribosyltransferase.

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Crystal structures and inhibit ...... ine phosphoribosyltransferase.

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prefLabel

Crystal structures and inhibit ...... ine phosphoribosyltransferase.

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Crystal structures and inhibit ...... ine phosphoribosyltransferase.

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Scientific Reports

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Crystal structures and inhibit ...... ine phosphoribosyltransferase.

@en

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Alena Zíková

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Dana Hocková

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David Terán

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Dianne T Keough

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Luke W Guddat

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Michal Česnek

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Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

The Genome of the African Trypanosome Trypanosoma brucei

The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Epidemiology of human African trypanosomiasis

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex

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10.1038/SREP35894

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6

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Trypanosoma brucei

crystal structure

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