Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.
about
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulationA novel role of Sprouty 2 in regulating cellular apoptosisThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitiSprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulationTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesSpred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signalingProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainA functional interaction between sprouty proteins and caveolin-1Coordinating ERK/MAPK signalling through scaffolds and inhibitorsc-Src activates endonuclease-mediated mRNA decay.Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pitsRegulation of sprouty stability by Mnk1-dependent phosphorylation.Cbl controls EGFR fate by regulating early endosome fusion.Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes.Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopEstablishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.The developing story of Sprouty and cancer.Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapyMet/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Long-range signal transmission in autocrine relays.Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.Differential regulation of transcription factors by location-specific EGF receptor signaling via a spatio-temporal interplay of ERK activation.ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cellsMUC4 overexpression augments cell migration and metastasis through EGFR family proteins in triple negative breast cancer cells.Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signalingExpression and functional role of sprouty-2 in breast morphogenesis.Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Endocytosis and intracellular trafficking of ErbBs.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing FieldMitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteinsImmunolocalization of sprouty-1 and sprouty-2 in developing rat lung
P2860
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P2860
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Sprouty2 attenuates epidermal ...... ly enhances Ras/ERK signalling
@nl
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@ast
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en-gb
type
label
Sprouty2 attenuates epidermal ...... ly enhances Ras/ERK signalling
@nl
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@ast
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en-gb
prefLabel
Sprouty2 attenuates epidermal ...... ly enhances Ras/ERK signalling
@nl
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@ast
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
Sprouty2 attenuates epidermal ...... y enhances Ras/ERK signalling.
@en
P2093
Chee Wai Fong
Esther Sook Miin Wong
Graeme R Guy
Jormay Lim
Permeen Yusoff
Wallace Y Langdon
P2860
P304
P3181
P356
10.1093/EMBOJ/CDF493
P407
P577
2002-09-01T00:00:00Z