The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
about
DLC-1: a Rho GTPase-activating protein and tumour suppressorDLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanismsGATA3 inhibits breast cancer growth and pulmonary breast cancer metastasisThe phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1DLC1 negatively regulates angiogenesis in a paracrine fashionDeleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liverInhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell linesOncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activitiesDeleted in liver cancer-1 (DLC1): an emerging metastasis suppressor geneRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Tumor-vascular interactions and tumor dormancyIntegrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survivalPreclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cellsA phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migrationDLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activityMicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancerA novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumorsEffects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migrationDeleted in liver cancer protein family in human malignancies (Review)The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrityThe Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarityTranscriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cellsLow expression of DLC1 is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancerDLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domainDLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathwayMetastasis suppressor genes at the interface between the environment and tumor cell growthRole of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progressionPilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinomaSilencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cellsDifferential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformationDerivation of molecular signatures for breast cancer recurrence prediction using a two-way validation approachLearning therapeutic lessons from metastasis suppressor proteins.Differential expression of ribosomal proteins in a human metastasis model identified by coupling 2-D liquid chromatography and mass spectrometry.Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphomaProteomic profiling identifies breast tumor metastasis-associated factors in an isogenic modelThe NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundleDeleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinomaDeleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.A comparative phosphoproteomic analysis of a human tumor metastasis model using a label-free quantitative approach
P2860
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P2860
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@ast
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@en
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@nl
type
label
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@ast
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@en
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@nl
prefLabel
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@ast
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@en
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@nl
P2093
P2860
P1433
P1476
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells
@en
P2093
Derek Sloan
Nicholas C Popescu
Steve Goodison
Virginia Urquidi
P2860
P304
P356
10.1158/0008-5472.CAN-04-3043
P407
P577
2005-07-01T00:00:00Z