An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells - Test2 - elhamkhani - TriplyDB

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

http://www.wikidata.org/entity/Q27704919

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Assessing histone demethylase inhibitors in cells: lessons learned.Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells Epigenetic Strategies to Boost Cancer Immunotherapies.KDM5 lysine demethylases are involved in maintenance of 3'UTR length.Twenty years of menin: emerging opportunities for restoration of transcription in MEN1.Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma.Inhibitors of Protein Methyltransferases and Demethylases.Marked for death: targeting epigenetic changes in cancer.Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.Follicular lymphoma, a B cell malignancy addicted to epigenetic mutations.Targeting TGF-β Signaling for Therapeutic Gain.Epigenetic regulation of RTK signaling.Regulation of oncogenic PI3-kinase signaling by JARID1B.MicroRNAs Change the Landscape of Cancer Resistance.A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine.Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions.JARID1 Histone Demethylases: Emerging Targets in Cancer.Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.The impact of non-genetic heterogeneity on cancer cell death.JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers.A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability.Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer.Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.Acquired Resistance to Drugs Targeting Tyrosine Kinases.The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila.Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair Epigenetic Targeting of Glioblastoma Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer The critical role of histone lysine demethylase KDM2B in cancer Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor

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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

http://www.wikidata.org/entity/Q27704919

description

2016 nî lūn-bûn

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2016 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2016 թվականի հուլիսին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@ast

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@en

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

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type

label

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@ast

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@en

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

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prefLabel

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@ast

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

@en

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

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Nature Chemical Biology

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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

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Amy Gustafson

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Brian K Albrecht

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Catherine Wilson

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Charles A Tindell

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Christopher Bailey

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David Arnott

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E Megan Flynn

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Erica Jackson

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Fei Lan

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Ganapati V Hegde

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P2860

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Processing of X-ray diffraction data collected in oscillation mode

The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA.

The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

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531-538

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scholarly article

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10.1038/NCHEMBIO.2085

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7

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12

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Matthew J Wongchenko

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2016-05-23T00:00:00Z

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1006461858

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27214401

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