The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity - Test2 - elhamkhani - TriplyDB

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

http://www.wikidata.org/entity/Q24554361

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Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1 Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours mTOR signaling in tumorigenesis Effects of AMP-activated protein kinase in cerebral ischemia Changes in components of energy regulation in mouse cortex with increases in wakefulness Involvement of AMPK in alcohol dehydrogenase accentuated myocardial dysfunction following acute ethanol challenge in mice HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5 AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle AMPK: a nutrient and energy sensor that maintains energy homeostasis AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo.Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1 Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance.Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2.Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.[EXPRESS] AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase.AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin.Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK

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P2860

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

http://www.wikidata.org/entity/Q24554361

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

The AMP-activated protein kina ...... whole-body insulin sensitivity

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The AMP-activated protein kina ...... whole-body insulin sensitivity

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The AMP-activated protein kina ...... whole-body insulin sensitivity

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type

label

The AMP-activated protein kina ...... whole-body insulin sensitivity

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The AMP-activated protein kina ...... whole-body insulin sensitivity

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The AMP-activated protein kina ...... whole-body insulin sensitivity

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prefLabel

The AMP-activated protein kina ...... whole-body insulin sensitivity

@ast

The AMP-activated protein kina ...... whole-body insulin sensitivity

@en

The AMP-activated protein kina ...... whole-body insulin sensitivity

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Journal of Clinical Investigation

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The AMP-activated protein kina ...... whole-body insulin sensitivity

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Alain Geloen

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Christophe Perrin

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Claudia Lenzner

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Daisy Flamez

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David Carling

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Emmanuel Gomas

http://www.w3.org/2001/XMLSchema#string

Erik A Richter

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Fabrizio Andreelli

http://www.w3.org/2001/XMLSchema#string

Frans C Schuit

http://www.w3.org/2001/XMLSchema#string

Jørgen F P Wojtaszewski

http://www.w3.org/2001/XMLSchema#string

P2860

Role of AMP-activated protein kinase in mechanism of metformin action

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

Central melanocortin receptors regulate insulin action

Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

AMP-activated protein kinase: the energy charge hypothesis revisited.

Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene.

New insights into sympathetic regulation of glucose and fat metabolism.

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91-8

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10.1172/JCI16567

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1

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111

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12511592

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