In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts - Test2 - elhamkhani - TriplyDB

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

http://www.wikidata.org/entity/Q24555640

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ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2 Muscleblind proteins regulate alternative splicing Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1 Comparative genomics and molecular dynamics of DNA repeats in eukaryotes Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains.HnRNP H inhibits nuclear export of mRNA containing expanded CUG repeats and a distal branch point sequence.There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Mechanisms of RNA-induced toxicity in CAG repeat disorders The unstable repeats--three evolving faces of neurological disease Deregulated microRNAs in myotonic dystrophy type 2 Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1)PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.Mechanistic determinants of MBNL activity Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophy Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.Evidence for RNA-mediated toxicity in the fragile X-associated tremor/ataxia syndrome.MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for assays of therapeutic molecules.Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte enhancer factor 2 (Mef2) {beta}-exon splicing.Dystrophia myotonia: why focus on foci?Molecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus.RNA structure of trinucleotide repeats associated with human neurological diseases.Characterization of MRP RNA-protein interactions within the perinucleolar compartment.Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy.High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.The FMR1 gene and fragile X-associated tremor/ataxia syndrome.Microsatellite repeat instability and neurological disease.Overexpression of CUGBP1 in skeletal muscle from adult classic myotonic dystrophy type 1 but not from myotonic dystrophy type 2.Autoregulated splicing of muscleblind-like 1 (MBNL1) Pre-mRNA.Structures of trinucleotide repeats in human transcripts and their functional implications.

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In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

http://www.wikidata.org/entity/Q24555640

description

2001 nî lūn-bûn

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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2001 թվականի հուլիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

@ast

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

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In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

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type

label

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

@ast

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

@en

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

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prefLabel

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

@ast

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

@en

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

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Nucleic Acids Research

P1476

In vivo co-localisation of MBNL protein with DMPK expanded-repeat transcripts

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P2093

J D Brook

http://www.w3.org/2001/XMLSchema#string

K Larkin

http://www.w3.org/2001/XMLSchema#string

M G Hamshere

http://www.w3.org/2001/XMLSchema#string

P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy

Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein

Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice

Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy

Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy

Transport of proteins and RNAs in and out of the nucleus

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR

Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy.

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2766-2771

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3023644

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10.1093/NAR/29.13.2766

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13

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29

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279409034

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11433021

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55763

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