Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.
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A hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strainsCrystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products.Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluationA comprehensive review of glycosylated bacterial natural products.Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.Muscarine, imidaozle, oxazole and thiazole alkaloids.Biosynthesis of natural products containing β-amino acids.Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.A designer bleomycin with significantly improved DNA cleavage activity.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria.Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.Biosynthetic mechanism for L-Gulose in main polar lipids of Thermoplasma acidophilum and possible resemblance to plant ascorbic acid biosynthesis.Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.MbtH homology codes to identify gifted microbes for genome mining.Amide compound synthesis by adenylation domain of bacillibactin synthetase.The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA.Expressed protein profile of a Tectomicrobium and other microbial symbionts in the marine sponge Aplysina aerophoba as evidenced by metaproteomics
P2860
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P2860
Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@ast
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@en
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@nl
type
label
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@ast
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@en
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@nl
prefLabel
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@ast
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@en
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@nl
P2093
P2860
P356
P1476
Comparative analysis of the bi ...... tallysomycin, and zorbamycin.
@en
P2093
Claudia Unsin
Evelyn Wendt-Pienkowski
Jane M Coughlin
Liyan Wang
Meifeng Tao
Sheng-Xiong Huang
P2860
P304
P356
10.1021/NP1008152
P577
2011-01-06T00:00:00Z