Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
about
Identification and characterization of a novel component of the human minichromosome maintenance complexCdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionCharacterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repairGeminin regulates neuronal differentiation by antagonizing Brg1 activityGenome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activitySelective killing of cancer cells by suppression of geminin activityPreventing re-replication of chromosomal DNA.Functional domains of the Xenopus replication licensing factor Cdt1Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinThe Non-Canonical Role of Aurora-A in DNA ReplicationGenomic instability in cancer.Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityHBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by GemininOrigin recognition and the chromosome cycleAurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorChromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosisPersistent telomere damage induces bypass of mitosis and tetraploidy.Replication licensing and the DNA damage checkpoint.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.Cell cycle adaptations of embryonic stem cells.Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damageManipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating GemininThe ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication."The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Revoking the cellular license to replicate: yet another AAA assignment.Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescenceHuman papillomavirus E7 induces rereplication in response to DNA damageScmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.
P2860
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P2860
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@ast
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@en
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@nl
type
label
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@ast
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@en
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@nl
prefLabel
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@ast
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@en
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@nl
P2093
P2860
P3181
P356
P1433
P1476
Human geminin promotes pre-RC ...... by stabilizing CDT1 in mitosis
@en
P2093
Andrea Ballabeni
Federica Marinoni
Laura Masiero
Marina Melixetian
Raffaella Zamponi
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600314
P407
P577
2004-08-04T00:00:00Z