Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis - Test2 - elhamkhani - TriplyDB

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

http://www.wikidata.org/entity/Q24567977

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Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.Oligomerization of ETO is obligatory for corepressor interaction The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor An important role for RUNX3 in human L1 transcription and retrotransposition The contribution of mouse models to the understanding of constitutional thrombocytopenia Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 Core Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic Opportunities Cohesin mutations in myeloid malignancies: underlying mechanisms Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1 The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1 AML1 interconnected pathways of leukemogenesis MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins The RUNX genes: gain or loss of function in cancer Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation A systematic analysis of a mi-RNA inter-pathway regulatory motif AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons Twist-2 controls myeloid lineage development and function Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1 Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog Runx1 function in hematopoiesis is required in cells that express Tek

P2860

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P2860

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

http://www.wikidata.org/entity/Q24567977

description

1996 nî lūn-bûn

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1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի ապրիլին հրատարակված գիտական հոդված

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@ast

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@en

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

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type

label

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@ast

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@en

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@nl

prefLabel

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@ast

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

@en

Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

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Proceedings of the National Academy of Sciences of the United States of America

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Disruption of the Cbfa2 gene c ...... locks definitive hematopoiesis

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A H Sharpe

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M Binder

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M Marin-Padilla

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N A Speck

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Q Wang

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P2860

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

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