Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design
about
Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)Computational design of a symmetric homodimer using -strand assemblyTeaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldAdhiron: a stable and versatile peptide display scaffold for molecular recognition applicationsDirected Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase.Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase.Monobodies and other synthetic binding proteins for expanding protein scienceA strategy for phage display selection of functional domain-exchanged immunoglobulin scaffolds with high affinity for glycan targets.Structural insights for engineering binding proteins based on non-antibody scaffoldsEpitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segmentHigh-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin DomainsMonobody-mediated alteration of enzyme specificityInhibition of RAS function through targeting an allosteric regulatory site.sNASP and ASF1A function through both competitive and compatible modes of histone binding.Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics.Crystallization and preliminary X-ray analysis of the C-type lectin domain of the spicule matrix protein SM50 from Strongylocentrotus purpuratus.In vivo characterization of the properties of SUMO1-specific monobodies.Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.Discovery of small molecule inhibitors targeting the SUMO–SIM interaction using a protein interface consensus approachBinding properties of SUMO-interacting motifs (SIMs) in yeast
P2860
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P2860
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Isoform-specific monobody inhi ...... tructure-guided library design
@ast
Isoform-specific monobody inhi ...... tructure-guided library design
@en
Isoform-specific monobody inhi ...... tructure-guided library design
@nl
type
label
Isoform-specific monobody inhi ...... tructure-guided library design
@ast
Isoform-specific monobody inhi ...... tructure-guided library design
@en
Isoform-specific monobody inhi ...... tructure-guided library design
@nl
prefLabel
Isoform-specific monobody inhi ...... tructure-guided library design
@ast
Isoform-specific monobody inhi ...... tructure-guided library design
@en
Isoform-specific monobody inhi ...... tructure-guided library design
@nl
P2093
P2860
P356
P1476
Isoform-specific monobody inhi ...... tructure-guided library design
@en
P2093
Akiko Koide
Ikenna Madu
John B Wojcik
Joseph A Piccirilli
Khue Truong
Nan-Sheng Li
Ryan N Gilbreth
P2860
P304
P356
10.1073/PNAS.1102294108
P407
P50
P577
2011-05-10T00:00:00Z