A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces
about
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library designStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainTeaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldEngineering of recombinant crystallization chaperonesCrystal structures of MBP fusion proteinsETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formationThe "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.Computational de novo design of a four-helix bundle protein--DND_4HB.A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.Application of protein engineering to enhance crystallizability and improve crystal properties.The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins.Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity.Accelerating phage-display library selection by reversible and site-specific biotinylation.The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffoldIdentification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.Discovery of high-affinity protein binding ligands--backwards.Stability and CDR composition biases enrich binder functionality landscapes.Monobodies and other synthetic binding proteins for expanding protein scienceNextGen protein design.Adnectins: engineered target-binding protein therapeuticsProtein binding specificity versus promiscuity.Structural insights for engineering binding proteins based on non-antibody scaffoldsEpitope-guided engineering of monobody binders for in vivo inhibition of Erk-2 signaling.Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold InteractionsSIMS: a hybrid method for rapid conformational analysis.Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions.Large scale production of phage antibody libraries using a bioreactor.Modular protein switches derived from antibody mimetic proteins.Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Designed hydrophilic and charge mutations of the fibronectin domain: towards tailored protein biodistribution.Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display.Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated proteinGeneration of high-performance binding proteins for peptide motifs by affinity clampingDevelopment of GFP-based biosensors possessing the binding properties of antibodiesCharacterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics.Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.Crystal structure of the human dual specificity phosphatase 1 catalytic domain.
P2860
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P2860
A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@ast
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@en
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@nl
type
label
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@ast
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@en
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@nl
prefLabel
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@ast
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@en
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@nl
P2093
P2860
P3181
P1476
A Dominant Conformational Role ...... ist Protein–Protein Interfaces
@en
P2093
Akiko Koide
Kaori Esaki
Ryan N Gilbreth
Sachdev S Sidhu
P2860
P304
P3181
P356
10.1016/J.JMB.2008.06.014
P407
P50
P577
2008-08-29T00:00:00Z