about
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinaseDifferential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblastsExposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-Kinase/Akt signaling pathway in mouse epidermal cellsMolecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinasesVisualization of biochemical networks in living cellsPHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthSuppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinMutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alphaActivation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2The PI3K-PDK1 connection: more than just a road to PKBSerum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationRegulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisS6K1 plays a critical role in early adipocyte differentiationA novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulinIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKAMammalian target of rapamycin: a central node of complex signaling cascadesS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayA PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansSpatial regulation of the mTORC1 system in amino acids sensing pathwayTcl1 enhances Akt kinase activity and mediates its nuclear translocationMechanotransduction in skeletal muscleProtein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated proteinUp-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's diseasePerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsAutophagy is essential to support skeletal muscle plasticity in response to endurance exercisemTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsAMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibitionStructural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop PhosphorylationCrystal structures of the S6K1 kinase domain in complexes with inhibitorsSli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Phosphorylation and activation of p70s6k by PDK1
@ast
Phosphorylation and activation of p70s6k by PDK1
@en
Phosphorylation and activation of p70s6k by PDK1
@en-gb
Phosphorylation and activation of p70s6k by PDK1
@nl
type
label
Phosphorylation and activation of p70s6k by PDK1
@ast
Phosphorylation and activation of p70s6k by PDK1
@en
Phosphorylation and activation of p70s6k by PDK1
@en-gb
Phosphorylation and activation of p70s6k by PDK1
@nl
prefLabel
Phosphorylation and activation of p70s6k by PDK1
@ast
Phosphorylation and activation of p70s6k by PDK1
@en
Phosphorylation and activation of p70s6k by PDK1
@en-gb
Phosphorylation and activation of p70s6k by PDK1
@nl
P2093
P921
P3181
P1433
P1476
Phosphorylation and activation of p70s6k by PDK1
@en
P2093
B A Hemmings
M Andjelkovic
P B Dennis
P304
P3181
P356
10.1126/SCIENCE.279.5351.707
P407
P577
1998-01-01T00:00:00Z