Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein - Test2 - elhamkhani - TriplyDB

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

http://www.wikidata.org/entity/Q24600358

about

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis.A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.The Cajal body and histone locus body The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines Cajal bodies and coilin--moving towards function SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia Coilin: The first 25 years Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1 UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development SMN in spinal muscular atrophy and snRNP biogenesis Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product.Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin.Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order.Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.The role of nuclear bodies in gene expression and disease.The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein.Sequence-specific interaction of U1 snRNA with the SMN complex In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems.The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.Tudor domains bind symmetrical dimethylated arginines.Plant coilin: structural characteristics and RNA-binding properties.Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy.Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm Regulation of neuronal differentiation by proteins associated with nuclear bodies.ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.In vivo kinetics of Cajal body components

P2860

Q21145787-328A0ADE-EAB2-4F34-8F1E-1784EFF354E4 Q21284169-F953674D-4FE0-4233-A2BF-35589ADAD29A Q21284170-F4254F7F-0C94-42DF-A24F-1C98EAE62210 Q24292040-6B4D2AD4-A89E-492A-9E4B-DCD6FC988690 Q24299793-3FBE139F-BBB3-430B-BA24-7CEEF29D50AA Q24306712-43C2E46D-46FC-45D5-AD45-F006CA16AA7B Q24312861-164EDCEE-35F5-4183-9E48-71C56441B253 Q24336921-1851D1DB-428F-4892-A0C7-C04B1A62F9F0 Q24536283-50CFCD1E-8BCD-4C58-B1AD-DA04EED591AA Q24630829-24F08E03-D7F7-4C13-9D5B-032FFFF37DEF Q24648864-A91BAA56-4768-453B-A968-D332C8190BCB Q24658020-933B268D-4DB9-49A2-986D-7699115809F1 Q24672790-7565EF41-E480-4C48-822A-B9F54EB1EC2C Q24676334-4C05DA3A-91C3-400D-B50A-23AD03F4615F Q24682443-E15C1D59-C3E1-43BD-BD2F-2C69C4733494 Q24683043-9F6D235B-3D31-4654-AF51-69A4054A6A47 Q28084574-CDA2A99C-2046-4900-B8ED-8C19C33B83DC Q28203025-6092B156-2945-4515-B225-30E10242CAA1 Q28484095-55EDDCF1-EE29-4F1D-8723-4121DAD81A80 Q29013847-5F961CA8-1EC7-4652-8E98-93AC3D790C1C Q30994078-011F637B-B74B-42B8-A601-3AC749BA64FC Q31032498-A998DDC3-93C7-49DC-B21C-5488DB4D1210 Q31121644-C7FD9804-E5DB-4E86-9846-D1D9D37AA555 Q33480004-7300823F-71B6-49E7-A74C-39EC785CBB2C Q33775603-C022FBF7-3461-4438-AB85-6E89FDF8F506 Q33810822-EAFD0B1B-31CC-4FCA-8F97-0F63E2A48556 Q34038183-A3763820-F7B8-40BD-A93A-0B91E8056F9A Q34060945-C11524A8-6F70-4DAC-9E08-80F840E87017 Q34086103-02C59855-B5BE-41A0-AFAD-841C6862461C Q34257423-3DB2C33D-FC95-4FF7-AA88-6067EF0A012C Q34324754-FD759BA2-B25E-4F33-8691-5632A14388A1 Q34407246-BDF04674-8514-4F5B-86D3-8678B76A22CE Q34425050-F5F653C1-F7A9-4F78-ADBE-575066E0C6C7 Q34426427-C3EFA528-5049-4599-86C8-42AB412FE5E8 Q34548288-678B4670-4159-4955-B2B4-1F1FD89DEC2B Q34762623-36EB5571-1B66-4A50-8A70-C756DD4F32C9 Q34985924-418E1D69-9776-48D4-8770-0703D096A8CA Q35072924-39017EFD-B7A1-4594-9BDB-01A311EF777B Q35114564-AAF7FE77-B941-4047-A37B-BF6C4E1E92A5 Q35121375-FD12BDF4-EDC2-40CE-80B3-9562E0E681F0

P2860

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

http://www.wikidata.org/entity/Q24600358

description

2001 nî lūn-bûn

@nan

2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@ast

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@en

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@nl

type

label

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@ast

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@en

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@nl

prefLabel

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@ast

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@en

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@nl

P1433

Q24600358-28CC4140-87B1-456C-B169-EDC3323AD2D5

P1476

Q24600358-6E65316B-C8E2-4F34-A96B-B301D9A0D088

P2093

Q24600358-37E90F82-959E-44B9-B869-9DB59D0E6DEC

Q24600358-5495ACB6-25BB-4983-A9FB-19707FA55766

Q24600358-A994673C-1E42-4A2F-8A56-55227B4CFE56

P2860

Q24600358-0273D536-918E-49EE-9397-B09260631643

Q24600358-0DC6F762-AD05-4A59-B24B-960DBB34C408

Q24600358-11903F36-A2A4-461D-B198-A4656D0D0805

Q24600358-2B4E5443-BEFF-436F-AE87-041220A7878D

Q24600358-2B636DF8-C927-4F2E-AB32-4B2792936FAB

Q24600358-2BA5E295-C00E-4E8B-BE44-96E4D42CB7FC

Q24600358-2D2D55B5-BFC7-4054-896A-C73F8427B44A

Q24600358-36214847-AB9D-4A44-962D-033AE6B458E8

Q24600358-3BD70406-13EC-4D9C-AFDE-D438672C5880

Q24600358-3C40BEE4-6751-40B5-A442-D7D2BAA7DDE3

P304

Q24600358-A7B9D739-BAEC-4189-8DCC-DC6A7CEC99E7

P31

Q24600358-5C8452CC-8E73-4B27-BB43-C5AD119DC097

P3181

Q24600358-1C591320-BB23-43BA-88E6-6C83A7BBA624

P356

Q24600358-F09BFB66-29E3-4590-A97C-5F51380509E3

P407

Q24600358-794A9696-3CF0-455A-AD2A-CB58B33331CC

P433

Q24600358-FFB90C20-6EE4-428C-A321-3BC652A4DE77

P478

Q24600358-F63921B3-F5B7-409F-9B8D-80326BA20DEF

P50

Q24600358-C7591013-CDB5-40CE-821E-2C6C67EFF937

P577

Q24600358-9736AFE4-EE67-4185-9B26-D542E5B4DB98

P5875

Q24600358-7F876208-EF24-4D5C-BC74-15BCB27241E5

P698

Q24600358-8DD54F3A-9FE2-4F45-8D50-EBA471E6B67F

P921

Q24600358-965E63BC-9A71-4095-BD92-4BDB9D49F4C2

Q24600358-9A51F582-6A22-4B3F-8984-5F4943F6669E

P932

Q24600358-CCCC380C-ED88-489F-B5BE-F80539E39A15

P3181

P356

P1433

Genes & Development

P1476

Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein

@en

P2093

K B Shpargel

http://www.w3.org/2001/XMLSchema#string

M D Hebert

http://www.w3.org/2001/XMLSchema#string

P W Szymczyk

http://www.w3.org/2001/XMLSchema#string

P2860

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.

Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C

Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems

Coiled bodies and gems: Janus or gemini?

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli

Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein

The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

P304

2720-2729

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1318734

http://www.w3.org/2001/XMLSchema#string

P356

10.1101/GAD.908401

http://www.w3.org/2001/XMLSchema#string

P407

P433

20

http://www.w3.org/2001/XMLSchema#string

P478

15

http://www.w3.org/2001/XMLSchema#string

P50

A. Gregory Matera

P577

2001-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11710823

http://www.w3.org/2001/XMLSchema#string

P698

11641277

http://www.w3.org/2001/XMLSchema#string

P921

spinal muscular atrophy

P932

312817

http://www.w3.org/2001/XMLSchema#string