SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta - Test2 - elhamkhani - TriplyDB

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta

http://www.wikidata.org/entity/Q24676334

about

Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis.A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly Gemin8 is required for the architecture and function of the survival motor neuron complex The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy.Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1 Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron Cross-talk between snurportin1 subdomains.Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.Molecular Mechanisms of Neurodegeneration in Spinal Muscular Atrophy Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1 In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein SMN in spinal muscular atrophy and snRNP biogenesis Dynamic control of Cajal body number during zebrafish embryogenesis.Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.Mechanisms and signals for the nuclear import of proteins Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.Tudor domains bind symmetrical dimethylated arginines.Depletion of SMN by RNA interference in HeLa cells induces defects in Cajal body formation.Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy.Pseudophosphorylated αB-crystallin is a nuclear chaperone imported into the nucleus with help of the SMN complex In vivo kinetics of Cajal body components Molecular and cellular basis of spinal muscular atrophy.Relative extended haplotype homozygosity signals across breeds reveal dairy and beef specific signatures of selection.Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.Nuclear import of spliceosomal snRNPs.Sm protein methylation is dispensable for snRNP assembly in Drosophila melanogaster.Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4.SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing.Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes Deciphering the assembly pathway of Sm-class U snRNPs.Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesis ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice Phosphorylation and the Cajal body: modification in search of function.Biogenesis of spliceosomal small nuclear ribonucleoproteins.

P2860

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P2860

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta

http://www.wikidata.org/entity/Q24676334

description

2002 nî lūn-bûn

@nan

2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@ast

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@en

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@nl

type

label

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@ast

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@en

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@nl

prefLabel

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@ast

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@en

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@nl

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P356

P1433

Human Molecular Genetics

P1476

SMN, the spinal muscular atrop ...... snurportin1 and importin beta

@en

P2093

Jason K Ospina

http://www.w3.org/2001/XMLSchema#string

Mark R Frey

http://www.w3.org/2001/XMLSchema#string

Michael D Hebert

http://www.w3.org/2001/XMLSchema#string

Usha Narayanan

http://www.w3.org/2001/XMLSchema#string

P2860

The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells

Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems

Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli

Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein

Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor

P304

1785-1795

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

415441

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P356

10.1093/HMG/11.15.1785

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

A. Gregory Matera

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2002-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

274434817

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P698

12095920

http://www.w3.org/2001/XMLSchema#string

P921

spinal muscular atrophy

P932

1630493

http://www.w3.org/2001/XMLSchema#string