Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair - Test2 - elhamkhani - TriplyDB

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

http://www.wikidata.org/entity/Q24603375

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DNA-damage-responsive acetylation of pRb regulates binding to E2F-1 Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair PALB2 is an integral component of the BRCA complex required for homologous recombination repair The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response Irofulven induces replication-dependent CHK2 activation related to p53 status DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2 PALB2: the hub of a network of tumor suppressors involved in DNA damage responses BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination Rad52 inactivation is synthetically lethal with BRCA2 deficiency Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings The FHA domain determines Drosophila Chk2/Mnk localization to key mitotic structures and is essential for early embryonic DNA damage responses.Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation.Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.DNA damage response mediated through BRCA1 CtIP mediates replication fork recovery in a FANCD2-regulated manner.Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.Mutations in the BRCT binding site of BRCA1 result in hyper-recombination NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Phosphatases in the cellular response to DNA damage.Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells MDC1 interacts with Rad51 and facilitates homologous recombination.Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

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P2860

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

http://www.wikidata.org/entity/Q24603375

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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type

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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MCB.24.2.708-718.2004

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Molecular and Cellular Biology

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

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David T Weaver

http://www.w3.org/2001/XMLSchema#string

Fen Xia

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Henning Willers

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Jagadish C Ghosh

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Jay H Chung

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Junran Zhang

http://www.w3.org/2001/XMLSchema#string

Sang Kim

http://www.w3.org/2001/XMLSchema#string

Simon N Powell

http://www.w3.org/2001/XMLSchema#string

Zhihui Feng

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P2860

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

DNA end-joining catalyzed by human cell-free extracts

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

Chk2 activation dependence on Nbs1 after DNA damage

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

Nonhomologous end joining and V(D)J recombination require an additional factor

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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708-18

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scholarly article

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4855605

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10.1128/MCB.24.2.708-718.2004

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2

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2004-01-01T00:00:00Z

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14701743

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phosphorylation

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343805

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