BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage - Test2 - elhamkhani - TriplyDB

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

http://www.wikidata.org/entity/Q28263101

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BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution BRCA1, a 'complex' protein involved in the maintenance of genomic stability Is there more to BARD1 than BRCA1?BRCA1 and Oxidative Stress Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.SNP-SNP interactions in breast cancer susceptibility.Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development.P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation Effects on human transcriptome of mutated BRCA1 BRCT domain: a microarray study.Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.Efficient prediction of human protein-protein interactions at a global scale.The role of BRCA1 in DNA damage response.Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.Detoxification: a novel function of BRCA1 in tumor suppression?Test for interaction between two unlinked loci.Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancer Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis.Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer.IQGAP1 is associated with nuclear envelope reformation and completion of abscission BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study.Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.BRCA1 in the DNA damage response and at telomeres The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.BRCA1 and BRCA2: different roles in a common pathway of genome protection.Unsolved mystery: the role of BRCA1 in DNA end-joining.BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells The human intra-S checkpoint response to UVC-induced DNA damage.Transcriptional regulation by p53.The DNA damage response: Balancing the scale between cancer and ageing.DNA damage sensing by the ATM and ATR kinases.

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BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

http://www.wikidata.org/entity/Q28263101

description

2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

@zh-cn

2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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name

BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

@ast

BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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type

label

BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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prefLabel

BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

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P1433

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Journal of Biological Chemistry

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BRCA1-BARD1 complexes are requ ...... g radiation-induced DNA damage

@en

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Grant A McArthur

http://www.w3.org/2001/XMLSchema#string

Karen Hobson

http://www.w3.org/2001/XMLSchema#string

Kienan Savage

http://www.w3.org/2001/XMLSchema#string

Kum Kum Khanna

http://www.w3.org/2001/XMLSchema#string

Megan Fabbro

http://www.w3.org/2001/XMLSchema#string

Simon N Powell

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

Chk2 activation dependence on Nbs1 after DNA damage

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

MDC1 is a mediator of the mammalian DNA damage checkpoint

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Regulation of p53 function and stability by phosphorylation

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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1749399

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10.1074/JBC.M405372200

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30

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279

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15159397

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phosphorylation