PALB2 is an integral component of the BRCA complex required for homologous recombination repair
about
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairEnhancement of RAD51 recombinase activity by the tumor suppressor PALB2.MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksRegulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1PALB2 regulates recombinational repair through chromatin association and oligomerizationBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksThe role of the human SWI5-MEI5 complex in homologous recombination repairBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairSTRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsSusceptibility pathways in Fanconi's anemia and breast cancerThe biological effects and clinical implications of BRCA mutations: where do we go from here?Role of Deubiquitinating Enzymes in DNA RepairDouble-strand break repair on sex chromosomes: challenges during male meiotic prophaseThe Fanconi anemia pathway and DNA interstrand cross-link repairFanconi anemia pathway defects in inherited and sporadic cancersBRCA1, a 'complex' protein involved in the maintenance of genomic stabilityStructure and function of WD40 domain proteinsRoles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA AnnealingPredictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized MedicineHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisRAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombinationCooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairLoss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppressionProbing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerExpanded roles of the Fanconi anemia pathway in preserving genomic stabilityRare germline mutations in PALB2 and breast cancer risk: a population-based study.Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motifFunctional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceThe breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
P2860
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P2860
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
PALB2 is an integral component ...... omologous recombination repair
@ast
PALB2 is an integral component ...... omologous recombination repair
@en
PALB2 is an integral component ...... omologous recombination repair
@en-gb
PALB2 is an integral component ...... omologous recombination repair
@nl
type
label
PALB2 is an integral component ...... omologous recombination repair
@ast
PALB2 is an integral component ...... omologous recombination repair
@en
PALB2 is an integral component ...... omologous recombination repair
@en-gb
PALB2 is an integral component ...... omologous recombination repair
@nl
prefLabel
PALB2 is an integral component ...... omologous recombination repair
@ast
PALB2 is an integral component ...... omologous recombination repair
@en
PALB2 is an integral component ...... omologous recombination repair
@en-gb
PALB2 is an integral component ...... omologous recombination repair
@nl
P2093
P2860
P3181
P356
P1476
PALB2 is an integral component ...... omologous recombination repair
@en
P2093
Junjie Chen
Michael S Y Huen
Shirley M H Sy
P2860
P304
P3181
P356
10.1073/PNAS.0811159106
P407
P577
2009-04-28T00:00:00Z