Chromosomal instability and cancer: a complex relationship with therapeutic potential - Test2 - elhamkhani - TriplyDB

Chromosomal instability and cancer: a complex relationship with therapeutic potential

Chromosomal instability and cancer: a complex relationship with therapeutic potential

http://www.wikidata.org/entity/Q24608609

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Diagnostic role of chromosomal instability in melanoma Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment Challenges of deciphering gastric cancer heterogeneity A role of WT1 in cell division and genomic stability Role of the Number of Microtubules in Chromosome Segregation during Cell Division Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Development of a Drosophila cell-based error correction assay.The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion Ploidy variation in multinucleate cells changes under stress.Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.New Insights in the Cytogenetic Practice: Karyotypic Chaos, Non-Clonal Chromosomal Alterations and Chromosomal Instability in Human Cancer and Therapy Response The molecular mechanism for nuclear transport and its application.Spindle microtubule dysfunction and cancer predisposition Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.WT1 interacts with MAD2 and regulates mitotic checkpoint function STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma Nucleosome assembly proteins get SET to defeat the guardian of chromosome cohesion Role of NEK2A in human cancer and its therapeutic potentials.STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome Chromosomal instability as a prognostic marker in cervical cancer.Correlation between smoking history and molecular pathways in sporadic colorectal cancer: a meta-analysis.Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis.Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells Numerical chromosomal instability mediates susceptibility to radiation treatment.High variability of genomic instability and gene expression profiling in different HeLa clones.Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.FANCA safeguards interphase and mitosis during hematopoiesis in vivo.A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.PARI overexpression promotes genomic instability and pancreatic tumorigenesis.

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

http://www.wikidata.org/entity/Q24608609

description

2012 nî lūn-bûn

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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2012年の論文

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2012年論文

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2012年论文

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Journal of Clinical Investigation

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Duane A Compton

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Samuel F Bakhoum

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P2860

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity

Mutations of mitotic checkpoint genes in human cancers

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

The centromere geometry essential for keeping mitosis error free is controlled by spindle forces

Chromosomes can congress to the metaphase plate before biorientation.

Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells

The spindle-assembly checkpoint in space and time

Genetic instabilities in human cancers

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10.1172/JCI59954

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Samuel F Bakhoum

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