about
Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnoverWSB1: from homeostasis to hypoxiaCullin-RING ligases in regulation of autophagyDrugging the undruggables: exploring the ubiquitin system for drug developmentNovel strategies to target the ubiquitin proteasome system in multiple myelomaThe role of the ubiquitin proteasome system in cerebellar development and medulloblastomaTargeting the ubiquitin pathway for cancer treatmentPosttranslational regulation of Akt in human cancerTargeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal TransitionEngagement of DYRK2 in proper control for cell divisionThe role of aberrant proteolysis in lymphomagenesisF-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.A MicroRNA/Ubiquitin Ligase Feedback Loop Regulates Slug-Mediated Invasion in Breast Cancer.Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Molecular genetics complexity impeding research progress in breast and ovarian cancers.Negative regulation of DAB2IP by Akt and SCFFbw7 pathwaysTargeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Protein ubiquitination in lymphoid malignancies.Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells.FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of SurvivinTargeting Cdc20 as a novel cancer therapeutic strategy.FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis.F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stressInhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.Regulation of the protein stability of EMT transcription factorsCurcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cellsFBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer.F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradationPharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitorsSmall molecule therapeutics targeting F-box proteins in cancer.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Roles of F-box proteins in cancer
@ast
Roles of F-box proteins in cancer
@en
type
label
Roles of F-box proteins in cancer
@ast
Roles of F-box proteins in cancer
@en
prefLabel
Roles of F-box proteins in cancer
@ast
Roles of F-box proteins in cancer
@en
P2093
P2860
P356
P1476
Roles of F-box proteins in cancer
@en
P2093
Hiroyuki Inuzuka
Pengda Liu
Zhiwei Wang
P2860
P2888
P304
P356
10.1038/NRC3700
P407
P577
2014-04-01T00:00:00Z
P6179
1020362180