Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Item

http://www.wikidata.org/entity/Q24616983

Q24616983

about

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells Replicative and chronological aging in Saccharomyces cerevisiae.A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis Advances in targeting signal transduction pathways Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging Down-regulating sphingolipid synthesis increases yeast lifespan Six plant extracts delay yeast chronological aging through different signaling pathways Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes Metabolic profiles of biological aging in American Indians: the Strong Heart Family Study Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid Peroxisome metabolism and cellular aging.The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.The bile acid membrane receptor TGR5: a valuable metabolic target.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats.The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae.Empirical verification of evolutionary theories of aging.Targeting DNA polymerase ß for therapeutic intervention.Growth culture conditions and nutrient signaling modulating yeast chronological longevity.A network of interorganellar communications underlies cellular aging.Lipids and cell death in yeast.Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan.Mechanisms by which different functional states of mitochondria define yeast longevity.Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression Peroxisomal catalase deficiency modulates yeast lifespan depending on growth conditions.Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.Mechanism of liponecrosis, a distinct mode of programmed cell death.

P2860

Q24617423-08B1EA8C-CD18-4695-A3E7-66F0F8B3FE52 Q24633177-46DD5155-A5FD-42B8-B8AF-AE23C9F02FC9 Q26774351-9601CBEB-67EE-4D35-8317-EE031B5C6052 Q27686983-C04C976B-4000-4230-8C6D-BC42154E9890 Q28077760-F25AF141-6F39-4194-B3B2-B52212D97267 Q28480463-6508C17C-CDE9-4E7D-BBA4-CC546204A0AC Q28817161-94EC0C3D-A498-4D25-9E47-3D209E408409 Q28817899-A53A6D23-69AA-40A9-8CE3-21D2089D9F28 Q28830549-F18D6399-054D-4679-9255-2D2C18B1B593 Q33577707-C96ADA6C-9D20-4EC5-91A4-80F5345B53A5 Q33737685-EF2D5899-8A4F-4B96-A624-419E126A8011 Q34117425-779C75F5-9B8E-4701-9D7A-1A957E7C7347 Q34194276-6C067FDB-6AD7-4E90-9F8E-4C136C8ADDEE Q34358930-729BC582-5895-4709-A80E-7819B069F483 Q34796539-E76A65DD-42DC-49F8-AD01-6C071F6CE71E Q34966717-A27B2A6D-B46D-46CC-A1A9-50D380539587 Q35082232-5F6A5A09-AFC5-44F5-9ECA-5A7CF73E03F7 Q35149607-644F7810-4507-4CF8-A01E-450E3464F220 Q35679353-7B17153E-51DE-4D0C-B8CA-2581721D4E98 Q36304181-61BD252A-4A2B-40BD-B16F-57DB7A700BB7 Q36442945-63CB48B4-63DD-47E9-AECD-D7082F4AAFCF Q36455187-B52004B1-A927-4F66-A707-C50832B78892 Q36832832-4BEE50C6-9EBE-4BD4-BA44-54530BB3327C Q36835814-0C0762C5-38B3-4A91-A945-28B21E251717 Q37298466-B026950E-AD0B-4CBF-BE72-4BCE2C353024 Q37423562-E9C7665A-7A4F-4817-8CF1-6B9287F62EB0 Q37489149-B17AEF03-59F7-4266-9A74-B04A367EBB53 Q38038608-A8E8AC3D-5F3D-49D0-A936-993787470430 Q38118667-00102E3C-EA95-4CC2-8817-4D791C1F3426 Q38151973-0E3E23AE-E128-40F8-912E-FD961F1298E1 Q38285035-E5F6FE04-5BA9-4AD1-BBCA-3B2B29B4BAF4 Q38376620-E6E3D81A-7ACE-46C7-AE8B-27518124CACA Q38515409-30222FCB-8BBA-4B95-8F2F-7ED5D1F0351A Q39208040-EB2B28F0-D43F-49A6-B4FF-B63ED00D770D Q39343002-BF7A937F-4A0B-4938-B523-AA359EAC6122 Q39430569-685D2782-8D22-4908-B198-8EA69FA55ACD Q39580230-970BBECE-CF34-4222-AAFE-589F92A88E91 Q41783250-5BB2561F-3991-4B3B-8766-4CC4AEA797C3 Q41808130-26860776-3C70-4FD6-B478-AF4BBB8F0619 Q41892669-378B4029-E2C2-4410-BA0B-66559DF3E87F

P2860

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Item

http://www.wikidata.org/entity/Q24616983

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue