The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset - Test2 - elhamkhani - TriplyDB

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

http://www.wikidata.org/entity/Q24625220

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Identification of druggable cancer driver genes amplified across TCGA datasets Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Cross-species models of human melanoma Origins of adult pigmentation: diversity in pigment stem cell lineages and implications for pattern evolution Serine, glycine and one-carbon units: cancer metabolism in full circle Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Chromatin signatures of cancer NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Epigenetic regulation in human melanoma: past and future Cross-species oncogenomics using zebrafish models of cancer Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells Clonal architectures and driver mutations in metastatic melanomas Conserved expression signatures between medaka and human pigment cell tumors Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3 IDH mutation impairs histone demethylation and results in a block to cell differentiation Genome-wide association study identifies novel loci predisposing to cutaneous melanoma The mutational landscape of chromatin regulatory factors across 4,623 tumor samples.Optimized cell transplantation using adult rag2 mutant zebrafish.Large-scale quality analysis of published ChIP-seq data.A meta-analysis of multiple matched copy number and transcriptomics data sets for inferring gene regulatory relationships.Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.Cancer epigenetics: a brief review.Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse Epigenetic regulation of epithelial-mesenchymal transition Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Genetics and epigenetics of the skin meet deep sequence.Transcriptional regulation and its misregulation in disease.Melanoma: clinical features and genomic insights.Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse.Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma.Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma De novo mutations in histone-modifying genes in congenital heart disease.Transcriptome profiling of CTLs regulated by rapamycin using RNA-Seq Zebrafish cancer: the state of the art and the path forward.

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P2860

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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The histone methyltransferase ...... noma and accelerates its onset

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The histone methyltransferase ...... noma and accelerates its onset

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The histone methyltransferase ...... noma and accelerates its onset

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The histone methyltransferase ...... noma and accelerates its onset

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The histone methyltransferase ...... noma and accelerates its onset

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Caitlin Bourque

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Christopher J Burke

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Laura Turner

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Lauriane Fritsch

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Mutations of the BRAF gene in human cancer

mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

The landscape of somatic copy-number alteration across human cancers.

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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10.1038/NATURE09806

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Slimane Ait-Si-Ali

Levi A Garraway

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50832126

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