Skp2: a novel potential therapeutic target for prostate cancer - Test2 - elhamkhani - TriplyDB

Skp2: a novel potential therapeutic target for prostate cancer

Skp2: a novel potential therapeutic target for prostate cancer

http://www.wikidata.org/entity/Q24625558

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High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms Targeting the ubiquitin pathway for cancer treatment Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.Prognostic impact of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas.Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents Roles of F-box proteins in cancer SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.Skp2 is a promising therapeutic target in breast cancer.Targeting Cdc20 as a novel cancer therapeutic strategy.Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.Expression of p14(ARF), p15(INK4b), p16(INK4a) and skp2 increases during esophageal squamous cell cancer progression.Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation.Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2.Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.Skp2-RNAi suppresses proliferation and migration of gallbladder carcinoma cells by enhancing p27 expression.Curcumin inhibits cell growth and invasion and induces apoptosis through down-regulation of Skp2 in pancreatic cancer cells Advances in androgen receptor targeted therapy for prostate cancer Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence Prostate cancer and the unfolded protein response.Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.MicroRNA regulation of F-box proteins and its role in cancer.The role of cullin proteins in gastric cancer.S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.Estimation of High-Dimensional Graphical Models Using Regularized Score Matching.SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types.Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation.Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells Skp2 and its emerging role in the pathogenesis of systemic malignancies besides breast carcinomas.

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Skp2: a novel potential therapeutic target for prostate cancer

http://www.wikidata.org/entity/Q24625558

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2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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Skp2: a novel potential therapeutic target for prostate cancer

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J.BBCAN.2011.09.002

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Biochimica et Biophysica Acta

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Skp2: a novel potential therapeutic target for prostate cancer

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Daming Gao

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Fazlul H Sarkar

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Hidefumi Fukushima

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Hiroyuki Inuzuka

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Lixin Wan

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Pengda Liu

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Wenyi Wei

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Zhiwei Wang

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P2860

Cell cycle, CDKs and cancer: a changing paradigm

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway

Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Clinical relevance of SKP2 alterations in metastatic melanoma

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

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Fazlul H. Sarkar

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