From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus - Test2 - elhamkhani - TriplyDB

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

http://www.wikidata.org/entity/Q24633183

about

A comparative analysis of exome capture RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability Enhancers: five essential questions TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease Biological, clinical and population relevance of 95 loci for blood lipids Histone H3K27ac separates active from poised enhancers and predicts developmental state Blood pressure loci identified with a gene-centric array RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome Genetics of RA susceptibility, what comes next?Single-Base Pair Genome Editing in Human Cells by Using Site-Specific Endonucleases Insights into blood lipids from rare variant discovery The degradation of apolipoprotein B100: multiple opportunities to regulate VLDL triglyceride production by different proteolytic pathways Exploring predisposition and treatment response--the promise of genomics Emerging directions in the genetics of atrial fibrillation Insights into obesity and diabetes at the intersection of mouse and human genetics Genome-scale neurogenetics: methodology and meaning Enhancer RNAs and regulated transcriptional programs Genetics of coronary artery disease Genetics of lipid traits and relationship to coronary artery disease The genetics and neuropathology of Alzheimer's disease Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk Genome-wide association studies of late-onset cardiovascular disease Needles in the genetic haystack of lipid disorders: single nucleotide polymorphisms in the microRNA regulome Network medicine approaches to the genetics of complex diseases Progranulin: at the interface of neurodegenerative and metabolic diseases Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway Prediction of Causal Candidate Genes in Coronary Artery Disease Loci Mechanisms of mutational robustness in transcriptional regulation Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease Sortilin mediates vascular calcification via its recruitment into extracellular vesicles A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer's Disease Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

P2860

Q21184017-D5FAEED9-6917-4953-867F-48B7C3B9FC5D Q21563361-8F10AC9D-7471-40DC-B757-5E46D14E5A5D Q21563383-6CC6FE2E-5E6E-431E-AFC0-308A3E5868B8 Q22121999-C741B1FF-BC4D-481A-AB54-1CBC414D9CF7 Q24299190-E9D3EEE0-F685-46E9-A1B1-7B1D56D51DAC Q24306825-5E54EA75-8B95-4217-A4FF-B92CAFDD1C18 Q24615584-F5B1E320-D021-4D56-84C7-B9B652C8649C Q24622541-8FFFE1C7-DBA4-4F9F-93DD-2AB35A895F26 Q24628758-BB286C9F-26D9-4306-A603-7CB3A28DD51D Q24630508-2311BB68-8FB8-4D19-A593-94B072B7BDB9 Q24630966-5A40784B-1836-4D3A-AB65-AED505CCBB97 Q26748869-C40DD62C-FFEB-4C1F-AFD9-8A1E30819EEE Q26771497-A75331C7-6E6D-4791-ABF6-1A0CF0081A67 Q26778260-930A183C-C65F-47EE-9F23-4D8B6DD64E9E Q26781370-6F39D0DE-0947-496B-9758-F37F04D8FA98 Q26799138-D9B7A4CF-9D98-46AD-8E4E-DD43F34A1C4B Q26824858-8631F676-97D3-4D10-9639-86A49913B8AA Q26851609-053D6631-4D34-41B9-AC41-17C4471487FB Q26852051-36150DC7-5530-4D4E-9E11-097BFB79B1FC Q26852866-CB4542EE-CEF5-4468-88A9-959F0C2BF037 Q26859474-938FC843-41F8-4533-90F4-5B79ECEBF1FA Q26865277-82AF2DA2-133F-46F5-9B74-2018D79B152B Q26866396-02C26D64-6E1D-448D-80B9-2B80CE482120 Q26995252-390FF741-DC95-40D4-BA35-483BAEBC38E3 Q26998097-23686A2A-3F15-4548-A9FD-5F76CC766FAE Q27003094-FD0FA948-29A3-4C5B-BB5A-259278F89C57 Q27012711-6E89A168-BBE3-4561-93E3-8D904E60E0A1 Q27015035-942C3898-3D13-496A-9B89-3F19828E9BF7 Q27024277-E989FB40-0683-4F83-BB95-898D528A463F Q27024421-0092731B-CBCD-47DA-A1A1-540AB54960A2 Q27309881-C5927397-F696-4366-B327-2C1E337A3C38 Q27311648-459520E0-253C-4FA7-9400-3910ED9EF453 Q27342192-8E1787B5-5574-4E65-970B-ACE047F1C974 Q28082759-11742D52-0785-4948-B53C-6A4EE10C744F Q28255651-C0C849B2-08FC-4E02-9B73-E00A5EC67630 Q28257511-EE636840-33C1-42F6-990B-2611AC0C9A1E Q28273951-FB164DCB-1333-4F99-9B71-179131EE2D0A Q28276977-1C5C2FC3-B6D6-4DDE-AA55-29090961B5AC Q28478042-849A83F7-0186-4681-8410-6BDAAA9A58CC Q28478309-FCAE485F-8889-4680-A355-1127FF4C596B

P2860

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

http://www.wikidata.org/entity/Q24633183

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@ast

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@en

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@nl

type

label

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@ast

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@en

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@nl

prefLabel

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@ast

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@en

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@nl

P1433

Q24633183-9B3A5997-995E-4C7D-950B-7FC39893147C

P1476

Q24633183-232DCC6B-FEE8-4654-8793-24EF4B32F06C

P2093

Q24633183-0D473166-127A-466A-8B4B-14643ED1436C

Q24633183-0E65A21B-19D7-4BC9-83A6-28259356F3FC

Q24633183-1E55DAE2-FCE2-4BD3-82F3-295B07A33429

Q24633183-22756E69-F47A-456C-9700-C464C36FB49C

Q24633183-287D4901-2A9C-44EE-9BD8-BBDB7CD5C6CF

Q24633183-3237A3C3-5AA4-47A1-B1A8-FB1212ED15F0

Q24633183-348BA96A-314C-4C80-9912-657C78C99C1B

Q24633183-40E7703F-5097-439F-A413-CFEB0DA8C0C1

Q24633183-467326C3-24F3-41B5-A982-D8AEDE938DA9

Q24633183-4B043C12-2AB3-447A-B5BE-4D8588647BAC

P2860

Q24633183-04D969A2-DD3F-458B-A66C-74050AF851E3

Q24633183-04E831A7-8560-489E-983E-E020A718992A

Q24633183-118B3DD7-3E08-4749-A4FD-3BCF6DD8BE0E

Q24633183-13623F7B-1613-4A98-9C34-B71DB5A25FCE

Q24633183-15F219BB-C600-42B5-86AD-1C2124A9F004

Q24633183-211FEAB8-CDE6-4591-BBF1-253CAEAFB851

Q24633183-23E71524-FC2B-4D7C-BE34-C0AEEF0547AC

Q24633183-2F21909F-F3C3-496E-A313-7F6D88B83C5B

Q24633183-3590701B-6136-4180-A352-F3F8F1971B76

Q24633183-3F71384D-1143-4B68-8B88-731D06D5E956

P2888

Q24633183-C7B682A1-0B95-4A97-97CE-07727D6382A7

P304

Q24633183-8312BC68-47EC-4728-8A7F-41931367C669

P31

Q24633183-0E80A8E4-6904-4C31-AEF8-B42EAB3B5934

P3181

Q24633183-21A485E1-545A-4983-B5B9-024018C2CB2B

P356

Q24633183-89CA9E86-29EA-42A2-A05B-C473BD4A35E6

P407

Q24633183-6152C0AE-6189-43B5-A7A1-FA386A325A2F

P433

Q24633183-3B34316D-6D27-4736-A69F-E4CC741516C0

P478

Q24633183-63020E59-780C-4FC1-BAA6-163C6CD44CFB

P50

Q24633183-0D48B133-3BDB-4BF3-80D7-E66033583FFB

Q24633183-2F47E26C-318B-454F-9D05-E733ED7D4D3A

Q24633183-31BD5EDB-1820-40E0-8F64-706F383F1C13

Q24633183-AC622BFD-F9E9-4566-BA6B-EC3422BD57F6

Q24633183-AE27FA9A-5989-45CC-82FC-72EDB548FB01

Q24633183-AFB03AEE-51BB-4869-8DA2-E5970F86A3A5

P577

Q24633183-72060BF9-E79D-4C12-A4FF-163C807522F4

P5875

Q24633183-433CDD1F-B7DA-4606-8277-AE66F44418F2

P6179

Q24633183-19514932-6C58-4EAB-9D84-C3FA2D0D8802

P698

Q24633183-53394749-B849-4E0C-AB0F-AE2904293341

P932

Q24633183-5998EB19-9283-4390-823C-74FFC39D0557

P3181

P356

P1433

P1476

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

@en

P2093

Alanna Strong

http://www.w3.org/2001/XMLSchema#string

Brian Muchmore

http://www.w3.org/2001/XMLSchema#string

Carlos R Morales

http://www.w3.org/2001/XMLSchema#string

Chad A Cowan

http://www.w3.org/2001/XMLSchema#string

Daniel J Rader

http://www.w3.org/2001/XMLSchema#string

Eric E Schadt

http://www.w3.org/2001/XMLSchema#string

Hui Li

http://www.w3.org/2001/XMLSchema#string

James P Pirruccello

http://www.w3.org/2001/XMLSchema#string

Jamie Wong

http://www.w3.org/2001/XMLSchema#string

Jennifer L Hall

http://www.w3.org/2001/XMLSchema#string

P2860

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes

Sortilin is essential for proNGF-induced neuronal cell death

Common variants at 30 loci contribute to polygenic dyslipidemia

Biological, clinical and population relevance of 95 loci for blood lipids

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

P2888

P304

714-719

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1764783

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NATURE09266

http://www.w3.org/2001/XMLSchema#string

P407

P433

7307

http://www.w3.org/2001/XMLSchema#string

P478

466

http://www.w3.org/2001/XMLSchema#string

P50

Ludmila Prokunina-Olsson

Kenechi G. Ejebe

Michael C. Phillips

M Orho-Melander

Victor Koteliansky

P577

2010-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45505966

http://www.w3.org/2001/XMLSchema#string

P6179

1007547666

http://www.w3.org/2001/XMLSchema#string

P698

20686566

http://www.w3.org/2001/XMLSchema#string

P932

3062476

http://www.w3.org/2001/XMLSchema#string